CRISPR in Drug Discovery 2023
Tuesday, 7 February 2023 to Wednesday, 8 February 2023

Posters

Britti
Elena Britti
University Of Oxford
1Phenocopying mitochondrial Parkinson’s disease patient phenotypes using CRISPRi in iPSC-derived neurons
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Arafat
Rafat Arafat
Andhra University
Palestinian Territory
2Development of 3( 4-methoxy benzylidiene ) -4-chromanone
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Souster
Emily Souster
Wellcome Sanger Institute
3Experimental pipelines for the validation of therapeutic target combinations from next generation dual CRISPR-Cas9 screens in cancer
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Kuenzel
Ulrike Kuenzel
AstraZeneca
4Arrayed CRISPR KO screens in renal cell models enable the identification of novel targets for Chronic Kidney Disease
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Penas
Ana Penas
Immunocore
5Use of CRISPR/Cas9 to support pre-clinical ImmTAX evaluation
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Silva
Romina Silva
Wellcome Sanger Institute
6GENOME-WIDE CRISPR–CAS9 SCREENS IN ORGANOIDS TO IDENTIFY CANCER DEPENDENCIES WITH CLINICAL IMPLICATIONS
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Russell
Paul Russell
Horizon Discovery
7Base Editor Screening Platforms to Characterize Performance of the Modular Components of Horizon’s Pin-PointTM Base Editing System
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Gernon
Grainne Gernon
AstraZeneca
8Coupling of cell cycle analysis to arrayed CRISPR immunofluorescence screening pipeline
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Kaulich
Manuel Kaulich
Vivlion GmbH
Germany
9Vivlion: Synthetic Lethality and Genetic Interaction Mapping at Scale
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Dunlop
Charlie Dunlop
AstraZeneca
10Arrayed CRISPR screening in primary human Tregs using a multi-colour flow cytometry endpoint
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Hunter
Morag Rose Hunter
AstraZeneca
11High-throughput lipid nanoparticle formulation to enable arrayed CRISPR screening in challenging cell models
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de Lint
Klaas de Lint
Amsterdam University Medical Center
Netherlands
12Full-genome isogenic/drug CRISPR screens identify novel genes involved in DNA replication, DNA repair, and sister chromatid cohesion
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Walter
Joanne Walter
Fida Biosystems
Denmark
13Flow Induced Dispersion Analysis (FIDA) in automated gRNA screening for CRISPR Cas development
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Caiazza
Maria Claudia Caiazza
University of Oxford
14Molecular basis of calcium homeostasis and dyshomeostasis in Parkinson's disease patient-derived dopaminergic neurons
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Schmidt
Henrik Schmidt
Myllia Biotechnology GmbH
Austria
15A genome-scale CROP-Seq screen reveals mediators of T cell signaling
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Hayward
Penny Hayward
Phoremost
16PHOREMOST: DRUGGING THE UNDRUGGABLE® for the next generation of therapies
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Teboul
Lydia Teboul
Mary Lyon Centre at MRC Harwell
17Capturing the unpredictability of CRISPR/Cas9 genome editing outcome in animal models.
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Montag
Katharina Montag
Axxam SpA
Italy
18CRISPR/Cas9 as integrative tools in neurological disease models and drug screening platforms
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Edwards
Harry Edwards
University of Nottingham
19Linking CRISPR Cas adaptation and the SOS Response
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Adam
Salome Adam
Astrazeneca
20Long-term proliferation arrayed CRISPR screening by colour competition assay at scale
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Byrne
Ann Byrne
bit.bio discovery
Austria
21Single-cell CRISPR knockout screen in iPSC derived ioGlutamatergic Neurons​
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Gabellini
Chiara Gabellini
University of Pisa
Italy
22Multiple CRISPR/Cas approaches to model human diseases using the teleost zebrafish: the case-study of Sotos syndrome, an example of syndromic autism with peculiar craniofacial alteration
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Schmidt
Tiziana Schmidt
University of Pisa
Italy
23Nanogenetic design of a photo-activatable Split Cas9 for in vivo delivery and gene editing
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Bradley
Jenna Bradley
Astrazeneca
24Arrayed CRISPR screening in primary small airway epithelial cells for the discovery of modulators of cellular senescence.
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Quarantotti
Valentina Quarantotti
AstraZeneca
25Validation of sensitisation targets using a long-term proliferation arrayed CRISPR screening platform.
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Kalinka
Alex Kalinka
CRUK
26Unbiased benchmarking of 8 different sgRNA design algorithms for building smaller and better KO libraries
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Hillis
Jennifer Hillis
Cancer Research UK-AstraZeneca Functional Genomics Centre
27Genome-wide pooled CRISPR screening in primary T cells at the Functional Genomics Centre (FGC), a partnership between AstraZeneca and Cancer Research Horizons
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Weise
Frank Weise
Natural and Medical Sciences Institute
Germany
28CRISPR for modelling neuropsychiatric disorders in vitro: Evaluating heterozygous gene variants in front of an isogenic background
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Petkovic
Maja Petkovic
AMSBIO
29CRISPR Systems for Drug Discovery
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Honarnejad
Kamran Honarnejad
Evotec SE
Germany
30CRISPR platform for Target Identification and Validation at Evotec
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Veprik
Anna Veprik
Novo Nordisk
31Genome-Wide CRISPR Screening to Identify Regulators of Hepatic Insulin Signalling
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Zhang
Ziki (Zhiqiang) Zhang
Astex Pharmaceuticals
32Using CRISPR tiling screens to identify functional regions of MAP2K1
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Nicke
Barbara Nicke
Nuvisan ICB GmbH
Germany
33Genome-wide CRISPR/Cas9 screen for the identification of novel YAP1/TAZ modulators
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Huang
Justin Huang
DEM BioPharma
United States
34A Co-culture with Human Myeloid Phagocytes (CHoMP) CRISPR platform to discover novel Don’t Eat Me (DEM) and Eat Me (EM) signals in an unbiased, systematic identification via intercellular CRISPR screens
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Nicke
Barbara Nicke
Nuvisan ICB GmbH
Germany
35Functional Genomics: Versatile Tools for Target Validation, Model Generation, and Biomarker Studies
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Franks
Sarah Franks
University of Oxford
36Consolidating high content imaging, fluorescent mitophagy reporters and mitochondrial functionality readouts into a multi-platform CRISPRi-based screen in SH-SY5Y
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Heon-Roberts
Rachel Heon-Roberts
University of Oxford
37A dual CRISPRi and CLEM approach to investigate the effects of aggregating proteins in neurodegeneration
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Humble
Stewart Humble
NINDS & University of Oxford
38CRISPRi-based Functional Genetic Interaction Mapping in PD and FTD/ALS
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Hewitson
Mark Hewitson
Agilent Technologies
39A New Poster Abstract
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Migenda Herranz
Anabel Migenda Herranz
CYTOSURGE
Switzerland
40FluidFM®: A technology to revolutionize precision single cell biology
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Count: 40