Posters

Chris Morris

STFC

2West-Life: A Virtual Research Environment for Structural Biology

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Mymoona Akhter

Faculty of Pharmacy, Jamia Hamdard

India

3Computational design and validation of some novel, non pteridine analogs as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitorsors

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M. Mumtaz Alam

Faculty of Pharmacy, Jamia Hamdard

India

4Novel pyrazole–pyrazoline hybrids as antimalarial agents: their synthesis and 3D-QSAR studies

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Laura Aitken

University of St. Andrews

5The Identification and Characterisation of Small Molecule Human ABAD Inhibitors as Therapeutics in Alzheimer’s Disease

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Kristian Bruce

GSK

6VST

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Hayley Saunders

MRC Technology

7Identification and characterisation of novel positive allosteric modulators of the Dopamine D1 Receptor

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Laurence Arnold

MRC Technology

8Development of disease modifying anti-osteoarthritis compounds targeting Matriptase

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Sururat Adigun

MRC Technology

9Screening ubiquitinated MALT1 to identify novel inhibitors

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Sandor Snoeijers

Pepscope BV

Netherlands

11Kinase Profiling using Peptide Arrays and Mass Spec as a Tool to Predict the Effect of Kinase Inhibitors on Patients

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Sandor Snoeijers

Pepscope BV

Netherlands

12Kinase Profiling Using Peptide Arrays and Phosphoproteomics

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Sandor Snoeijers

Pepscope BV

Netherlands

13Kinase Profiling Using Peptide Arrays and Phosphoproteomics

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Sandor Snoeijers

Pepscope BV

Netherlands

14Kinase Profiling Using Peptide Arrays and Phosphoproteomics

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Sandor Snoeijers

Pepscope BV

Netherlands

15Kinase Profiling Using Peptide Arrays and Phosphoproteomics

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David McCoull

MRC Technology

16Screening for Inhibitors of CSF-1R – A Novel Target in the Treatment of Alzheimer’s Disease.

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Vendela Parrow

Dep of Medical Sciences

Sweden

17SciLifeLab drug discovery

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Apeksha Shrivastava

Jamia Hamdard

India

21Pharmacophore Modeling & Docking Studies of DPP-IV enzyme Inhibitors

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Israa Al-ibadi

University of salford

22Selective Recruitment of Glucocorticoid Receptor By Non-Steroid Ligands: Molecular Study of Novel Anti-Cancer Therapies

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Helen Plant

AstraZeneca Pharmaceuticals

23Evaluation of venoms as a source of novel ligands for drug discovery

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Badri Ampolu

Sygnature Discovery

24Drug Discovery Approaches for Epigenetic Targets

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Lauren Eades

ApconiX Ltd

26Delivering CiPA to the Client

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Kevin Jones

Corning Life Sciences

Netherlands

27In Vitro Hepatotoxicity Profiling Using Corning® Epic® Label-Free Technology with Primary Hepatocytes, HepG2 Cells, and Corning HepatoCells

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Kevin Jones

Corning Life Sciences

Netherlands

28Cancer Therapeutic Screening in Tumor Spheroids Co-Cultured with Fibroblast and Immune Cells using Corning® Spheroid Microplates

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Kevin Jones

Corning Life Sciences

Netherlands

29Three Dimensional Hepatotoxicity Screening using Corning® HepatoCells, the Spheroid Microplate and the SCREEN-WELL® Hepatotoxicity library

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Kevin Jones

Corning Life Sciences

Netherlands

30High Content Screening of Corning® HepatoCells for Hepatotoxicity

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Eve Rogers

University of Liverpool

31Exploring the Potential of the Physico-Mechanical Environment and Circadian Timing in Adult Stem Cell Differentiation

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Emma Shanks

CRUK Beatson Institute

32Iterative Data Multiplexing Identifies Therapeutic Candidates for Oral Squamous Cell Carcinoma

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Nuno Alves

Stevenage Bioscience Catalyst

33DiscoverAssist

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Nuno Alves

Stevenage Bioscience Catalyst

34DiscoverAssist

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Jey Jeyakumar

Plasticell Ltd

35A stem cell screening platform for discovery of chondrogenic small molecules and their drug targets

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Muhammad Awais

Liverpool University

36Development of Small Molecule Inhibitors of Cyclophilin D to Protect Mitochondrial Function ˗ Potential Use for the Treatment of Acute Pancreatitis

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Roy Edward

BioStatus Limited

37Monitoring Cell Death in Real-Time/Time-Lapse Studies

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Ruediger Bader

Hamamatsu Photonics UK Ltd

39Ca²⁺ mobilization assay to predict GPCR ligands safety profile in Cor.4U human cardiomyocytes

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Simon Lydford

Molecular Devices (UK) Ltd

40Assessing 2D & 3D cellular responses with the EarlyTox suite of cell viability and apoptosis reagents for plate reader and imaging systems

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Simon Lydford

Molecular Devices (UK) Ltd

41Morphometric Characterisation of Cancer Spheroid Cultures using 2D/3D Image Analysis & Confocal Imaging Techniques

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Andrew Green

DiscoverX

42Profiling Compounds in Human Primary Cell BioMAP® Systems for Drug Discovery and Development in Cancer Immunotherapy

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SHWETA SHARMA

Jamia Hamdard

India

43In-silico studies of novel, non-pteridine analogues as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors

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Apeksha Shrivastava

Jamia Hamdard

India

44Drug Designing of novel DPPIV enzyme Inhibitors using Computer Aided Techniques

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Martine Ballinger

MRC Technology

46Solving the screening bottleneck: 96-well format HT reformatting and expression of IgGs for screening.

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Arune Balaikaite

MRC Technology

47T-cell epitopes, virus-like particles and extracellular loop fusions for challenging antibody generation

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SUNIL KUMAR

SHOOLINI UNIVERSITY

India

48Immunostimulatory potential of a bioactive fraction (PBC) from Phyllostachys bambusoides in SRBC immunized balb/c mice

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Cristina-Ileana Ureche

SIRION BIOTECH

Germany

51Improving in vivo Application Through High Quality Viral Vector Technologies – Purity, Concentration & Vector Design as Key for Successful AAV Experiments

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Laurie Gordon

GSK

53A platform for measuring and understanding intracellular cell concentration

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Joseph Bradley

Scitegrity Limited

54Automated detection and control of controlled substances

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Adam Dickinson

Nexcelom BioScience

55A high-throughput image cytometry-based screening method for the detection of IL2-induced peripheral blood mononuclear cell-mediated cytotoxicity

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Adam Dickinson

Nexcelom BioScience

56A high-throughput 3D tumor spheroid screening method for drug discovery using imaging cytometry.

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Adam Dickinson

Nexcelom BioScience

57Comparison of label-free cell cytotoxicity image cytometric detection method to CellTiter-Glo®

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Adam Dickinson

Nexcelom BioScience

58Real-time Caspase 3/7 measurement of suspension and adherent cells using the Celigo® image cytometer

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Steve Brough

Key Organics

59Building a Diverse and Experimentally-Curated Fragment Library

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Andrea Lindemann

InSphero AG

Switzerland

60Characterization and application of 3D Multi-donor Human Liver Microtissues for predictive DILI testing

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Andrea Lindemann

InSphero AG

Switzerland

61A Novel Standardized In Vitro Islet Model System for Efficacy and Toxicity Testing in Pancreatic β-cells

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John Cuff

AstraZeneca

63Compounds in the right place at the right time!

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Sapna Desai

GSK

65Promiscuous Activation of the Mast-Cell Degranulation Receptor, Mrgprx2, Induces Adverse Histamine-Like Reactions in Clinically Relevant Species

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Bill Primrose

Ripptide Pharma

67A chemoenzymatic route to novel macrocycles

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J Malcolm Wilkinson

Kirkstall Ltd

68Organ on a chip : A Status Report on Worldwide Developments

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Bryon Ricketts

Avacta Life Sciences Ltd

69Generation and Formatting of Affimer® Biotherapeutics for the Inhibition of the PD-L1/PD-1 Pathway

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Chloe Koulouris

University of Sussex

72Characterisation of serine racemase as a novel approach to modulating NMDA receptor function

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james bennett

University of Oxford

73Chemical Tools For Exploring the Biology of the Epigenetic Readers BRD9 and BRD7.

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Thomas Christott

University of Oxford

75A Chemical Tool to investigate the biology of SMARCA and PB1(5)

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Silvia Cirillo

Sheffield University

76De novo designed short antimicrobial peptide as a potential siRNA delivery vector targeting cancer cells

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Steven van Helden

Pivot Park Screening Centre

Netherlands

77The European Lead Factory: an efficient open-innovation platform with unique screening capabilities

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Mark Abbott

Peak Proteins Ltd.

78X-RAY CRYSTAL STRUCTURES OF HITS FROM A FRAGMENT BASED DISCOVERY PROGRAM ON EPIGENETICS TARGET BRD3

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Thierry Calmels

Bioprojet biotech

France

79A Duplexed assay for measurement of GPCR mediated calcium signaling and PathHunter -arrestin recruitment from single well using FDSS/-cell functional drug screening system

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Amaury Fernandez-Montalvan

Bayer

Germany

80Fast and Accurate Assessment of Binding Kinetics in HTS Format with kPCA and Genedata Screener

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Michael Rogers

University of Liverpool

81Small molecule inhibitors for Cyclophilin D

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Carol Trim

Canterbury Christ Church University

82The antimicrobial effects of animal venom

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Danielle McCullough

Canterbury Christ Church University

83Targeting breast cancer signalling pathways with animal venoms

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Astrid Noerenberg

upcyte technologies GmbH

Germany

84Driving primary liver cells into proliferation - the upcyte® technology

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Jonas Stenberg

Ridgeview Instruments AB

Sweden

85Real-time interactions on living immune cells

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Sarah Ash

AstraZeneca

86Development of a Co-culture Assay Amenable to HTS

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Victoria Miller

University of Sussex

87Identification of Potent and Selective Inhibitors to Investigate the Role of the Epithelial Sodium Channels in Neurodegeneration

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Muddasar Farooq

Sekisui XenoTech

88Evaluation of Ketoconazole and its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters

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Gina Washbourn

University of Liverpool

89The Synthesis and Biological Evaluation of Carbamoyl Triazoles as Potential Antituberculosis Protease Inhibitors

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Mohd Fuad Rahmat Sam

University of Liverpool

90Human Cell Perfusion Bioreactor Systems Utilising Biomaterials to create 3D Tissue Analogs of Stem Cell Niches for the Production of Red Blood Cells

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Friedrich Reinhard

GSK

Germany

91Two-dimensional thermal proteome profiling and chemoproteomics as orthogonal drug target profiling strategies

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malcolm haddrick

AstraZeneca

92Characterisation of stem cell derived cardiomyocyte spheroids using the CardioExcyte platform

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Qiuyu Wang

Manchester Metropolitan University

93Investigating the response of gastric cancer cells to arabinoxylan extracts in vitro

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Yasmine Alsaidi

Royal Holloway University of London

94Affinity peptidomics and the selection of protein markers for the early non-invasive detection of breast cancer

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Ingo Montenbruck

Proteros Biostructures

Germany

95Commonalities and differences in protein production, kinetic profiling and X-ray crystallography supporting drug discovery processes for biologicals versus small molecules

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Giorgia Salvagiotto

Cellular Dynamics International, A FujiFilm Company

United States

96Human iPSC-derived Tissues as Novel Translational Models for Drug Discovery.

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patrick courtney

tec-connection

Germany

97Recent developments in the Smart Laboratory Enabled by Standards in Laboratory Automation

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Roslyn Lloyd

PerkinElmer

98Imaging in cancer immunology: Phenotyping of multiple immune cell subsets in-situ in FFPE tissue sections

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Matt Vassey

Aurelia Bioscience

99Novel 3-D micro-scaffold platform: A paradigm shift for cell-based screening

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Therese Dynes

AstraZeneca

100Accelerated plate generation for Screening assays and reduction in Design-Make-Test cycle timelines are facilitated by Automation and Process improvements in Compound Management

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John Malone

CN BioInnovations

101A microfluidic, 3D cell culture system for the mechanistic investigation of liver diseases and determination of compound efficacy.

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Peter Strapps

PerkinElmer

102Detection and Modulation of Extracellular Matrix Protein Deregulation in Human Prostate Carcinoma Cells Using AlphaLISA Technology.

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Louise Healy

Aurelia Bioscience

103Macrophage responses under hypoxic conditions – a drug target for the discovery of anti-cancer agents?

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Amy Prosser

Sygnature Discovery

1043D Cell Culture: A Valuable Tool For Drug Discovery

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Paul McGillan

University of Liverpool

105Design, Synthesis and Biological Evaluation of Novel 7-Amino Pyrazolopyrimidine Anti-Bacterial Compounds for the Treatment of Onchocerciasis and Lymphatic Filariasis.

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David Whalley

AstraZeneca Pharmaceuticals

106High-throughput determination of the binding kinetics of nuclear hormone receptor antagonists using TR-FRET

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Monica Mantri

University of Oxford

107Screening for small molecule inhibitors of a cytoplasmic Terminal Uridylyl Transferase implicated in the modulation of Let-7 tumor suppressor miRNA

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Aisha Alsfouk

Strathclyde University

108Development of selective IKKα inhibitors as a treatment for prostate cancer therapy

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Andrew Brierley

AstraZeneca

109Increasing Assay Precision by the Evaluation and Mitigation of Systematic Discrepancies in Compound Dispenses Following a Comparison of Technology Platforms

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Oliver Wehmeier

acCELLerate GmbH

Germany

110Testing Compounds for Drug Induced Phospholipidosis Using Assay Ready Cryopreserved HepG2 Cells

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Donna Potts

Agilent technologies

111Antibody Characterization Enabled by Automated Affinity Purification, Deglycosylation, IdeS Digestion, and Reduction

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Katie Duffell

University of Sussex

112Development of a Tool Inhibitor of GCN5 Towards the Treatment of ccRCC

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Julie Rainard

University of Dundee, ESC Newhouse

113Showing target engagement for HTS hits with Microscale Thermophoresis

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Kristian Bruce

GlaxoSmithKline

114Industrialising a Volatile Solvent Transfer (VST) method to incorporate un-weighable compounds into the GSK Screening collection

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Md. Saiful Islam

University of Oxford

116Controversial Story of a Fe(II) and 2OG dependent Oxygenase, JmjD6

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Jim Gallagher

University of Liverpool

United States

117Developing therapies for the iconic disease alkaptonuria (AKU)

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Jim Gallagher

University of Liverpool

United States

118In vitro models of bone formation and bone resorption

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Sharon Bahia

PHE Culture Collections

119The EBiSC Catalogue

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Sharon Bahia

PHE Culture Collections

120Utilisation of iPSCs in Drug Discovery and Development

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Fiona McCann

NDORMS, University of Oxford

121Localised inhibition of histone acetylation may offer a novel therapeutic strategy to down regulate the myofibroblast phenotype in Dupuytren’s disease

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Daniel Martinez Molina

Pelago Bioscience AB

Sweden

122The Cellular Thermal Shift Assay (CETSA) - Label free, physiologically relevant target engagement measures in the intact cell

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Chris Evans

TTP Labtech

124Eliminating the false negatives in ATP-luminescence cell health assays by the use of a phenotypic based approach.

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Chris Evans

TTP Labtech

125A practical solution for phenotypic screening of a full compound library

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Gareth Jones

TTP Labtech

126Enriched datasets from in-house compound libraries using direct dilution methods in 1536 well plates

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Gareth Jones

TTP Labtech

127Low volume automated liquid handling for studying autophagic pathway, and cellular transduction in cancer cells

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Sarah Payne

TTP Labtech

128Multiplexed cell and bead based assays in a no wash format for biologics screening and characterisation

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Sarah Payne

TTP Labtech

129Beating Moore’s law but now what? Reduced sample prep cost for genetic analysis

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Karl Syson

John Innes Centre

130Remodelling α-glucan pathways in Mycobacterium tuberculosis and identifying new drug targets

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Adrian Kinkaid

MIP Diagnostics Limited

131Automatic Reactor for the Synthesis of MIP Nanoparticles

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Francesco Canfarotta

MIP Diagnostics Limited

132Imprinted Polymeric Nanoparticles for Diagnostic Applications

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Liz Quinn

Takara Bio USA, Inc.

France

133Footprint free genome editing via CRISPR/Cas9 and single cell cloning of human iPS cells

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Michael Elser

Takara Bio Europe

France

134Novel miniprep system for rapid purification of recombinant proteins and antibodies on high-capacity membranes

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Keisha Hearn

Astex Pharmaceuticals

135Generation and characterisation of crizotinib-resistant NSCLC models

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Katie Chapman

Domainex

136An Important role for TBK1/IKKε in IP10 signalling: A potential intervention in COPD

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Jana Wolf

Domainex

137Fragment screening against the lysine methyltransferase G9a using Microscale Thermophoresis

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Cristina-Ileana Ureche

SIRION BIOTECH

Germany

138Optimization of in vitro gene therapies with LentiBOOSTTM, a novel clinical applicable adjuvant improving LV transduction efficiency in hematopoietic cells

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Irene Hallyburton

University of Dundee

139DDD107498: A Preclinical Candidate for Malaria

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Amanda Jones

PerkinElmer

141Setting up a 3D High Content Imaging Assay to study Cholestasis using the Opera Phenix High Content Screening System

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Dale Athey

Orla Protein Technologies

142A protein-engineering approach to assay development for in-process analysis during antibody-drug conjugate manufacture: a proof of concept with trastuzumab

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Michael Thomas

Drug Discovery Unit

143DDD853651; A Preclinical Candidate for the Treatment of Visceral Leishmaniasis

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Priyanka Dutta-Passecker

Axol Bioscience Limited

144Serum-free Human iPSC-Derived Cardiomyocytes for in vitro testing

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Priyanka Dutta-Passecker

Axol Bioscience Limited

145Implementation of High Throughput Screening on iPS cells

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Jennifer Riley

University of Dundee

146Giving CYP the slip…Establishment of an in vitro CYP51 inhibition assay to prioritise new chemical entities for Chagas’ Disease.

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Laura Turunen

FIMM

Finland

147Acoustic dispensing in development of personalized medicine drug sensitivity and resistance testing (DSRT) platform at FIMM

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Richard Wall

University of Dundee

148Defining drug mechanism of action: leveraging phenotypic hits against kinetoplastids

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Rachel Harvey

AstraZeneca

149An Evaluation of iPSC-CM Cell Lines for Calcium Imaging Cardiotoxicity Screening

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Matthew Burnham

Astrazeneca

150Characterisation of stem cell derived cardiomyocyte spheroids using the CardioExcyte platform

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Neil Mallon

Caltag Medsystems Ltd

151Identification of Biomarkers for Ovarian Cancer using xxpress® qPCR

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Maja Petkovic

AMS Biotechnology (Europe) Limited

152Next generation high capacity DNA damage detection assay for chemotherapy and genotoxic compound screening

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Ann Macdonald

Thermo Fisher Scientific

154A robust platform for generation and high throughput functional analysis of human iPSC-derived cardiomyocytes

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Spencer Campbell

Bicycle Therapeutics

155Discovery and characterisation of a CAIX-targeted Bicycle-Drug Conjugate.

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Peter Craggs

GSK

156Autofluorescent and Active – the Use of Fluorescence Lifetime Technology to Eliminate False Fluorescent Hits

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Peter Craggs

GSK

157Long Fluorescence Lifetime or Label-free? An Evaluation of Fluorescence Lifetime Technology for High Throughput Screening

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Roland Leathers

Thermo Fisher Scientific

Switzerland

158Profiling Inhibitors with Full-Length LRRK2 in both Biochemical & Cellular Formats

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Valerie Legris

Electrospinning Company

159Growing hiPSC-derived cardiomyocytes on Mimetix scaffold improves their function

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Lauri Paasonen

UPM-Kymmene Corporation

Finland

1603D cell culture, assay automation and 3D printing demonstrated with a novel xeno-free hydrogel derived from wood

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Claire McWhirter

AstraZeneca

161Assay Design Impacts on Hits Found During Primary Screening

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Martin Brown

AstraZeneca

162Investigating Alternative Pathway Mechanisms of AhR Antagonism

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Roja Hadianamrei

University of Sheffield

163Short amphiphilic peptides as new tools for gene delivery

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Margaret Huggett

DDU, University of Dundee

164Fragment Library Design, Synthesis & Expansion: Nurturing a Synthesis and Training Platform

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Margaret Huggett

DDU, University of Dundee

165Small polar compound library for TB drug discovery

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Margaret Huggett

DDU, University of Dundee

166Fragment Library Design, Synthesis & Expansion: Nurturing a Synthesis and Training Platform

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Margaret Huggett

DDU, University of Dundee

167Small polar compound library for TB drug discovery

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Margaret Huggett

DDU, University of Dundee

168Designing and building lead-like diversity libraries

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Margaret Huggett

DDU, University of Dundee

169Identification and prioritisation of hits from whole cell phenotypic screening of Mycobacterium Tuberculosis in the context of treatment shortening

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Tony Hope

Drug Discovery Unit

170Innovative Targets: The DDU Approach

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Samantha Hitchin

Cancer Research UK Manchester Institute

171CRUK:MI Advancing Drug Discovery Through Partnership

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Jennifer Bishop

Kirkstall

172Can Organ-on-a-Chip Replace Animal Testing of Drug and Chemical Safety?

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Samantha Hitchin

Cancer Research UK Manchester Institute

173CRUK:MI Advancing Drug Discovery Through Partnership

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Hinnah Campwala

Essen BioScience

174Continuous live-cell proliferation, clustering and viability assays for T-cells, PBMCs, monocytes and B-cells

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Mike Kerins

Cambridge Bioscience

175Miniaturization Of Singulex® and Luminex® Multiplex Based Cytokine Assay With Wall Less 96 Well Plates

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Mike Kerins

Cambridge Bioscience

176Immunotherapeutic Target Identification & Drug Screening Using Patient Tumour & Blood Samples Cultured Under Conditions That Replicate The Metastatic Niche

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Louise Affleck

Cisbio Bioassays

France

179Sensitive detection of GPCR-mediated ERK1/2 phosphorylations in various cellular models with the HTRF® advanced phospho-ERK1/2 kit

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Louise Affleck

Cisbio Bioassays

France

180HTRF® phospho-protein platform facilitates the dissection of signaling pathways involved in insulin resistance and metabolic disorders

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Louise Affleck

Cisbio Bioassays

France

181Implement HTRF® phospho-protein assays at every step of the drug discovery process: from in vitro to in vivo models

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Carl Jarman

Labcyte Inc.

United States

182Identification of PI3K inhibitors with an Automated Echelon Fluorescence Polarization Assay Using the Labcyte Access Workstation with Integrated Labcyte Echo 525 and 555 Liquid Handlers and the EchoQualified Reservoir

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Daniella Steel

Horizon Discovery

183A generic strategy for CRISPR - Cas9-mediated gene tagging

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Hannes Hahne

OmicScouts GmbH

Germany

184Identifying drug targets and target engagement markers using proteome-wide CETSA and ITDR

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Gesa Rascher-Eggstein

Nanion Technologies GmbH

185Cardiac drug and safety screening platforms for the future: automated patch clamp, extracellular field potential and impedance approach

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Emma Cains

Allergan Biologics

186Application of Automation/Technology for Improving Cell Line Development

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Peter Djali

IntelliCyt Corporation

United States

187A High Throughput Screening Assay to Assess PD-LI/2 Antibody Checkpoint Inhibitors

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Cleoper Paule

Charles River Discovery

188HTMS Screen for Enzyme Inhibitors Utilising the Apricot ADDA for On-Line Sample Desalting

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Weili Li

University of Chester

189Investigating the response of gastric cancer cells to arabinoxylan extracts in vitro

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Tristan Pritchard-Meaker

Axiogenesis AG

Germany

190Human iPSC-derived cardiomyocytes for HTS to assess acute as well as chronic drug-induced cardiotoxicity

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Count: 167