Posters

Marie Labus

Newcastle University

1Development of disease modifying drugs for osteoarthritis

Profile Poster

Chris Morris

STFC

2Visualizing Disease-Gene Relationships

Profile Poster

Jayme Dahlin

Mayo Clinic

United States

3Promiscuous in vitro bioassay activity of the natural product garcinol, a reported inhibitor of histone acetyltransferases

Profile Poster

Basma Al-sudani

salford university

4Selection of Circular ssDNA Aptamers against Sirtuin1 protein by SELEX Methodology

Profile Poster

Dermott O'Callaghan

The Research Network

5The Research Network - Building New Therapeutic Ventures

Profile Poster

Jacqueline Naylor

MedImmune

United States

8Use of Incretin Receptor Knock-Out β–cell Lines for Dual Agonism Drug Discovery

Profile Poster

Gemma Kinsella

Dublin Institute of Technology

Ireland

9GPR21, A novel target for Type 2 Diabetes

Profile Poster

Pilaslak Akrachalanont

University of strathclyde

10Anthelminthic Drug Target Identification and Validation

Profile Poster

Radu Tamaian

ICSI Rm.Valcea

Romania

11In silico modelling of the biodistribution of therapeutic immunoconjugates with thiazolic payload

Profile Poster

Helen Boyd

AstraZeneca

Sweden

12Building an understanding of type IV bromodomains.

Profile Poster

Helen Boyd

AstraZeneca

Sweden

13Hunting for hits for E3 ligases

Profile Poster

Agathe Devaux

CELENYS

France

14HYALURONIC ACID SCAFFOLD FOR 3D CELL CULTURE

Profile Poster

Kate Enright

Fisher BioServices

15Understanding the effect of short term temperature excursions on cell therapies

Profile Poster

Emma Shanks

CRUK Beatson Institute

16Genes within the 3q26-29 amplicon present novel therapeutic candidates for oral cancer

Profile Poster

Emma Shanks

CRUK Beatson Institute

17Academic Drug Discovery within the UK - a reassessment

Profile Poster

shazia khan

student

Pakistan

18DNA analyser

Profile Poster

Steve Brough

Key Organics

19Building a Diverse and Experimentally-Curated Fragment Library

Profile Poster

Steve Brough

Key Organics

20Rapid Virtual Library Screening and Synthesis for Selective Hit Identification

Profile Poster

Elsa Breau

AMSBIO

21High throughput in vitro microtumor model for drug screening

Profile Poster

salha tawati

strathclyde university

22 DEVELOPMENT OF DPP-IV INHIBITORS FOR THE TREATMENT OF TYPE 2 DIABETES

Profile Poster

Robert-Jan Lamers

Abundnz B.V.

Netherlands

23A novel ultrasensitive assay for bioanalytical studies with innovative medicines

Profile Poster

Banusha Rajeenthira

MRC Technology

26A protein engineering approach to explore the binding mode for inhibitors of the de novo purine biosynthetic enzyme PAICS

Profile Poster

Afrah Sattikar

MRC Technology

27Validation and optimisation of novel antagonists of MIF

Profile Poster

Daniel Tams

Roslin Cells

28Banking and Characterisation of Human Induced Pluripotent Stem Cells for Drug Discovery Applications

Profile Poster

Alan Morgan

University of Liverpool

Afghanistan

29Using nematode worm models of human neurological diseases to identify novel therapeutic drugs and mechanisms of action.

Profile Poster

Catherine Gouveia

Cytome Technologies Ltd

30Next Generation Protein Profiling Using inCYT

Profile Poster

François Degorce

Cisbio Bioassays

France

31How do HTRF® epigenetic binding domain assays perform compared to other technologies ?

Profile Poster

François Degorce

Cisbio Bioassays

France

32New cell-based HTRF® assays for the exploration of Wnt signaling pathway

Profile Poster

François Degorce

Cisbio Bioassays

France

33Universal HTRF® phospho-protein platform : from 2D, 3D, primary cells to patient derived tumor cells

Profile Poster

Alasdair Robertson

SAL Scientific Ltd

34Optimised Conditions for Cell Growth in Defined Media

Profile Poster

Kelly Davidge

Kirkstall

35Advances in in vitro testing: the route to replace animal testing

Profile Poster

Antonella Ragnini-Wilson

University of Rome Tor Vergata

Italy

36A novel cell-based assay to identify compounds acting in central nervous system re-myelination

Profile Poster

Daniela Natale

IRBM Science Park S.p.A.

Italy

37Identification and validation of a new class of HDAC inhibitors able to induce HbF in thalassemic erythroid precursors.

Profile Poster

Thalia Carreno

University of Sussex

Mexico

38A structure-based approach to identifying novel modulators of the Nrf2 transcription pathway

Profile Poster

Tyrrell Norris

AstraZeneca

Sweden

40Identification of small molecule inhibitors of FoxO1 using large scale transiently transfected assay-ready cells in HTS

Profile Poster

Elsa Breau

AMSBIO

41Monitoring the interplay between oxygen availability and metabolism in tumor biology using high throughput measurements of 3D cell models

Profile Poster

Alan Sandercock

MedImmune

42High content screening of cell-surface-selected antibodies in a complex 3D tumour cell model

Profile Poster

Christoph Sachse

NMI TT Pharmaservices

Germany

43Comprehensive profiling of signal transduction pathways in tumour tissues, using DigiWest, a novel multiplex protein profiling method

Profile Poster

Christoph Sachse

NMI TT Pharmaservices

Germany

44Characterisation of β-catenin complexes by Chromobody-based intracellular co-immunoprecipatation and DigiWest protein profiling

Profile Poster

Valerie Legris

Electrospinning Company

45Liver cancer cells grown in 3D in the Mimetix scaffold regain a primary-like phenotype

Profile Poster

David Calvo

GSK

Spain

46High Throughput Measurement of Mitochondrial Membrane Potential

Profile Poster

Anders Hanning

Episentec AB

Sweden

47Label-Enhanced SPR Improves the Detectability of Label-Free Surface Plasmon Resonance Analysis 100x

Profile Poster

Anne Burke

EuroScitech

49Difficult to Express Proteins made easy with the Drosophila S2 based ExpreS2 system’

Profile Poster

Joanne Walter

EuroScitech

50LabMinds Revo – an automated solution preparation system that releases scientific minds from the burden of procedural lab tasks.

Profile Poster

Cassandra Rigby

MRC Technology

52Identification of novel, potent inhibitors of PAICS within the de novo purine synthetic pathway to target the treatment of metastatic breast cancer

Profile Poster

Ahmad Kamal

MRC Technology

54Utilisation of the InCELL Hunter™ Target Engagement Cell-Based Assay for Profiling of ULK1 Inhibitors.

Profile Poster

Rachel McMenamin

Mission Therapeutics

55Evaluating fluorescence lifetime technology for identification and characterisation of DUB inhibitors

Profile Poster

Richard Griesbach

NMI

Germany

56Premium Screening Tools and Target Validation Services

Profile Poster

Alan Fisher

PerkinElmer

57Image Based Quality Control of Cell-Based Assays Utilizing the

Profile Poster

Alan Fisher

PerkinElmer

58Simultaneous detection of IL-6 and IL-8 secretion by cell lines using AlphaLISA and AlphaPlex 545 reagents

Profile Poster

Eva Hansson

AstraZeneca R&D Mölndal

59Mineralocorticoid Receptor Reporter Gene Assay – optimisation for medium to high throughput screening.

Profile Poster

Daniel Wilcock

AstraZeneca

60Taking RAS Screening to the Next Dimension

Profile Poster

Andrea Traube

Fraunhofer IPA

Germany

61High-throughput manufacturing of human epidermal models

Profile Poster

Laurent Brault

Exquiron Biotech AG

Switzerland

62Direct delivery of functional proteins or peptides into eukaryotic cells by a novel bacteria-based technology

Profile Poster

Giorgia Salvagiotto

Cellular Dynamics International, A FujiFilm Company

United States

63Novel iPSC-derived cellular systems for in vitro disease modeling.

Profile Poster

Gary Allenby

Aurelia Bioscience

64Phenotypic screening of iPS-derived cardiomyocyte toxicity ina novel 3D cell culture system

Profile Poster

Fiona Jeganathan

Institute of Cancer Research

65Correlating thermal stability & ligand lipophilicity with KDM4A protein-ligand crystallography success.

Profile Poster

Gareth Davies

AstraZeneca

66Screening by SPR Workflow and Software for Efficient Data Processing

Profile Poster

Violeta Niculescu

ICIT Ramnicu Valcea

Romania

68New metallic complexes as a potential drugs for urease activity inhibition

Profile Poster

Rebecca Dixon-Steele

AstraZeneca

69A 1536 Well Epic® Assay Development Process

Profile Poster

Rhiannon McNeill

University of York

72Metal-binding Proteins as Novel Urothelial Biomarkers of Cadmium Exposure

Profile Poster

Spencer Campbell

Bicycle Therapeutics

73Bicyclic peptide Drug Conjugates (BDCs) targeting MT1-MMP – a new type of anticancer agent

Profile Poster

David Allcock

Sygnature Discovery

75Design, Synthesis and Optimisation of a Novel, Proprietary Fragment Library Using Biophysical Techniques

Profile Poster

Russell Green

Beckman Coulter UK Ltd

76Automated 3D Cell Culture and Screening by Imaging and Flow Cytometry

Profile Poster

Russell Green

Beckman Coulter UK Ltd

77Automated NGS Sample Prep with Integrated Data Management and Reporting Tools

Profile Poster

Jana Kaiser

MISSION Therapeutics

78Inhibitors of USP30 for the treatment of Parkinson’s disease and other mitochondrial dysfunctions

Profile Poster

Ana Pires

Mission Therapeutics

79Targeting USP11 for the treatment of platinum-resistant ovarian cancer

Profile Poster

Lisa Igelmann

MISSION Therapeutics

80Development of a drug discovery platform targeting SUMO specific proteases

Profile Poster

Jan Carsten Pieck

MERCK KGaA

Germany

81cHTS process @ MERCK KGaA

Profile Poster

Jan Carsten Pieck

MERCK KGaA

Germany

82Enabling HCS in 1536 well format

Profile Poster

Berwyn Lloyd

Beckman Coulter UK Ltd

88Automation of Micro RNA and Total RNA Purification from tissues using the Agencourt RNAdvance Tissue Kits and Biomek NXP Span 8 Laboratory Automation Workstation

Profile Poster

Berwyn Lloyd

Beckman Coulter UK Ltd

89Automate Like a Pro: Fully Integrated System for ELISA and Cell Viability Absorbance Assays

Profile Poster

Vasco Meneghini

Institute Imagine

Italy

90Intracerebral lentiviral gene therapy enables stable and widespread biodistribution of therapeutic enzymes in the brain of non-human primates

Profile Poster

Jacqueline Rippington

Gilson Scientific ltd

91A Flexible Workflow for Automated Kinase Selectivity Profiling

Profile Poster

Jean-Marc D'Angelo

Hamamatsu Photonics France

92Optogenetics: A Bright Future for Voltage Gated Ion Channels

Profile Poster

Jean-Marc D'Angelo

Hamamatsu Photonics France

93BRET2 assay using the FDSS/μCELL: monitoring cell surface-receptor internalization and intracellular trafficking

Profile Poster

Jean-Marc D'Angelo

Hamamatsu Photonics France

94Electric Field Stimulation (EFS) of human iPSC-derived neuron using Hamamatsu FDSS/μCELL

Profile Poster

Alex Macpherson

UCB

95A Comparison of High Throughput Screening Techniques for Interrogating Membrane Bound, PPI Targets

Profile Poster

Stephen Hobson

Newcastle University

96Radiosynthesis and Pre-clinical Imaging of [18F]Fluoroethyl choline

Profile Poster

SHAH KHAN

OMAN MEDICAL COLLEGE

Oman

97Phytochemical screening, total phenolic and flavonoid contents, evaluation of antioxidant potential and Lipoxygenase (5-LO) inhibitory activity of aerial parts of Haplophyllum tuberculatum (Forssk) A. Juss: An Omani traditional medicine

Profile Poster

Roland Leathers

Thermo Fisher Scientific

Switzerland

98ExpiCHO™: Surpassing the Performance of 293 in a Transient CHO Expression System

Profile Poster

Mark Soave

University of Nottingham

99Use of an NLuc-BRET System to Investigate Ligand-Binding to the Human β1-adrenoceptor

Profile Poster

Hernani Silvestre

Evotec

100Industrial Use of Medium-Throughput Fragment Screening by Crystal Soaking

Profile Poster

Hernani Silvestre

Evotec

101Industrial Use of Medium-Throughput Fragment Screening by Crystal Soaking

Profile Poster

Faiza Durrani

School of Biological Sciences,P.U.pakistan.

102Cost effective production of biologically active recombinant ovine growth hormone via SRP secretory system

Profile Poster

Amy Heptinstall

Newcastle University

103Development of ERK5 Inhibitors for Anti-Cancer Therapy

Profile Poster

Sylvain Blanc

Charnwood Molecular

104Direct Targets Identification of a Bioactive Compound Using Chemical Biology

Profile Poster

Simon Lydford

Molecular Devices (UK) Ltd

105Development of a cell-based potassium-chloride transporter assay using a new FLIPR Potassium Assay Kit

Profile Poster

Simon Lydford

Molecular Devices (UK) Ltd

106High throughput assays for characterizing the viability and morphology of 3D cancer speroid cultures

Profile Poster

Andrea Traube

Fraunhofer IPA

Germany

107Immediate drop on demand technology ï¿½ a new platform for cell applications in low-volume range

Profile Poster

Tristan Thwaites

Axol Bioscience Ltd.

108Characterisation of iPSC-derived Neural Stem Cells and Cerebral Cortical Neurons

Profile Poster

Nathalie MAUBON

HCS Pharma

France

109Development of neuroprotection model for Parkinson disease using High Content Screening

Profile Poster

Nathalie MAUBON

HCS Pharma

France

110Hepatotoxicity assays by High Content Analysis

Profile Poster

Peter Banks

BioTek Instruments

United States

111Validation of a Novel Tumoroid-Based Cell Culture Model to Perform 3D in vitro Cell Signaling Analyses

Profile Poster

Peter Banks

BioTek Instruments

United States

112Cellular Analysis of 3D Spheroid-Based Tumor Invasion Assays

Profile Poster

Simon Lydford

Molecular Devices (UK) Ltd

113Development of a platelet calcium flux assay using Fura-2, AM on the FlexStation 3 Multi-Mode Microplate Reader

Profile Poster

Priyanka Narasimhan

Domainex

114A novel approach to identifying lysine methyltransferase inhibitors

Profile Poster

Scott Cribbes

Nexcelom Bioscience Ltd

115A high-throughput direct cell counting imaging cytometry method for natural killer cell-mediated cytotoxicity detection

Profile Poster

Claire Tebbutt

Domainex

118An Important role for TBK1/IKKε in IP10 signalling: A potential intervention in COPD

Profile Poster

James Wilkinson

NanoTemper Technologies

Germany

119MicroScale Thermophoresis - Case Study on Automated Fragment Screening

Profile Poster

Nicola Bevan

Essen Bioscience

120IncuCyte(TM) Chemotaxis System: a new and enabling solution for directional migration assays

Profile Poster

Gillian Lovell

Essen BioScience

121Real time image-based quantification of phagocytosis in living cells using IncuCyte ZOOM®

Profile Poster

Adam Hyman

University of Leeds

122Are you measuring your protein correctly? Comparison between microvolume spectrometers

Profile Poster

Ian Willox

DiscoveRx

123Analysis of α-PD-1, α-PD-L1 and α-CTLA-4 Immune Checkpoint Antibodies in Human Primary Cell BioMAP® Oncology Systems

Profile Poster

Nadine Wilhelm

Fraunhofer IBMT

124A HUMAN SERUM ALBUMIN-BASED GENE DELIVERY SYSTEM FOR THE SAFE VIRUS-FREE APPLICATION IN GENE AND CELL THERAPY

Profile Poster

Scott Cribbes

Nexcelom Bioscience Ltd

125A rapid 3D tumor spheroid image cytometric analysis method for drug discovery.

Profile Poster

Isabel Patocchi

Tecan Schweiz AG

Switzerland

126Cytochrome P450 compound profiling

Profile Poster

Andrew Green

Discoverx

127Measuring Receptor Dimerization To Create Functional Cell-Based Assays for ~85% of the Interleukin Receptor Family

Profile Poster

Kate Feeney

Discoverx

128Rational design of dual kinase-bromodomain inhibitors for therapeutic polypharmacology

Profile Poster

Katherine Roper

Manchester Institute of Biotechnology

129Eve: Integration of machine learning with compound testing in a robot scientist

Profile Poster

Masakazu Kobayashi

ZoBio BV

Netherlands

130From Genes to protein-ligand structures; a work-flow tuned for structural characterization by solution NMR

Profile Poster

James Wilkinson

NanoTemper Technologies

Germany

131NanoTemper Prometheus NT.48 - High Precision Protein Fodling Analysis in Drug Discovery and Formulation Development by nanoDSF

Profile Poster

Rachel Doidge

Aurelia Bioscience Ltd

132Implementation of the Tecan D300 digital dispenser improves accuracy and reproducibility of concentration response curves

Profile Poster

Michelle Potter

Peakdale Molecular

133CYP Inhibition: To Pool or Not to Pool

Profile Poster

Faiza Durrani

School of Biological Sciences,P.U.pakistan.

134cost effective production of biologically active recombinant ovine growth hormone via SRP secretory system

Profile Poster

Faiza Durrani

School of Biological Sciences,P.U.pakistan.

135Molecular characterization of ovine growth hormone and growth hormone binding protein of Bubalus bubalus revealed the presence of novel amino acid.

Profile Poster

Laurent Brault

Exquiron Biotech AG

Switzerland

136Customised solutions for successful hit discovery

Profile Poster

Ian Gowers

Charles River

137Development of a p75NTR Homodimer NanoBRET Assay and Identification of Neurotrophins Capable of Modifying the NanoBRET signal

Profile Poster

Agnes Martin

Cancer Research Technology

138Biophysical techniques for hit validation during small molecule drug discovery

Profile Poster

Cristina Alli

Cancer Research Technology

139Strategies for targets sensitive to Redox Cycling Compounds

Profile Poster

Cristina Alli

Cancer Research Technology

140Screening for small molecule inhibitors of a transcription factor target implicated in cancer

Profile Poster

Rupert Satchell

Sygnature Discovery

141A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs

Profile Poster

Dan Gare

Avacta Life Sciences

142Allosteric inhibition of FcgRIIIa-IgG interactions using Affimers

Profile Poster

Dan Gare

Avacta Life Sciences

143Fibrinogen targeted Affimers can successfully modulate fibrin clot lysis in the presence of plasminogen inhibitor

Profile Poster

Emily Rampling

Cambridge Bioscience

144Using Impedance-Based Approaches for Measuring Cell-Mediated Cytotoxicity and Antibody-Dependant Cell-Mediated Cytotoxicity (ADCC)

Profile Poster

Emily Rampling

Cambridge Bioscience

145PamGene’s Kinase activity profiling of tumor tissues of different origin

Profile Poster

Elena Tavkin

B CUBE, Technische Universität Dresden

Germany

146High-throughput microtubule gliding assay for drug screening

Profile Poster

Richard Kasprowicz

Phase Focus Ltd

147Label-free measurement of cell death using ptychographic imaging

Profile Poster

Linda Orren

Labcyte

United States

148Evaluation of combination treatment efficacy utilizing the Labcyte Echo® liquid handler and Echo® Combination Screen Software with reduced cost, increased throughput and flexibility in a PC3 viability assay

Profile Poster

Linda Orren

Labcyte

United States

150Identification of HDAC1 inhibitors with an automated Fluorogenic assay using the Labcyte Access Workstation with an integrated Labcyte Echo® liquid handler and Echo® Qualified Reservoir.

Profile Poster

Richard Somberg

Promega

United States

151Monitoring Intracellular Protein Interactions Using NanoLuc® Binary Technology (NanoBiT)

Profile Poster

Grainne Gernon

Cancer Research Technology

152Complementary approaches to study histone lysine demethylases (KDM)

Profile Poster

Scott Cribbes

Nexcelom Bioscience Ltd

153Consistently and accurately measure CAR T Cell concentration and viability using Cellometer image cytometry for adoptive cell transfer therepy

Profile Poster

Craig Malcolm

Promega UK Ltd

154Investigating the cellular interactions of BIRB796 analogs using a novel Chloroalkane capture tag

Profile Poster

Christian Schueller

PerkinElmer

Germany

155Phenotypic discovery and characterization of neuroprotective compounds relevant to ALS

Profile Poster

Miles Rackliff

IntelliCyt Corporation

156Profiling of a compound library biased toward Immunomodulating agents: HTS of Immunophenotype, Viability, Proliferation and Cytokine secretion on a single platform

Profile Poster

Miles Rackliff

IntelliCyt Corporation

157HIGH THROUGHPUT FLOW SCREENING ASSAYS TO PROFILE CELL-MEDIATED KILLING

Profile Poster

Miles Rackliff

IntelliCyt Corporation

158Utilising High Throughput Flow to Screen for Differential Sensitivity of Primary Cells to Immunosuppressive Compounds

Profile Poster

Miles Rackliff

IntelliCyt Corporation

159Better Antibody Screening Using IntelliCyt’s iQue Screener AND Comparison of FMAT and Using the iQue Screener for Cell-Based Antibody Library Screening

Profile Poster

Count: 139