Authors

Discussion

Leishmaniasis remains a major public health problem in various regions of the world. A significant obstacle to controlling the disease is the high rate of treatment failure and relapse among patients. Recently, quiescence was suggested as a mechanism Leishmania use to avoid drug inhibition and immune system clearance, but knowledge gaps remain regarding the molecular and metabolic adaptations underlying entry to and exit from a quiescence state. 

We aim to characterise the transcriptional changes associated with emergence from a quiescent state induced by nutrient deprivation in Leishmania mexicana. Quiescent promastigotes were reactivated by nutrient replenishment, and RNA was extracted over a time course.