Authors
D Herbert1; 1 University of Pennsylvania, United States Discussion
This lecture will review current controversies over the ability of gastrointestinal nematodes to develop drug resistance and adapt to an aging host. The core of the data presented will center on unpublished studies that take an experimental evolution approach to understand how the rodent hookworm Nippostrongylus brasiliensis adapts to different murine hosts that have various levels of Type 2 inflammatory capability. Using a variety of biochemical and transcriptional approaches, this work will highlight the dynamic interplay between a model metazoan and its mammalian host. 
