Abstract

PerkinElmer has developed assay technologies, microplates, multi-mode plate readers and Imaging instrumentation + reagents for Drug Discovery research. The HTRF and AlphaLISA homogeneous, orthogonal assay platforms are robust, flexible and can be applied to a large range of drug targets within Infection Biology for small and large molecule drug research. This presentation highlights: Homogeneous assays for:  viral antigen quantification  detecting immune-response e.g. cytokine release + phospho-protein signalling assays  virus:host interaction e.g. Biochemical PPI assays for COVID-19 therapeutic discovery  anti-viral antibodies Cell-based strategies for:  Britelite Plus Luciferase viral neutralisation assays  ATPlite luminescence viral cytopathic effect assays (CPE)  PhenoVue Cellular Imaging Reagents + Phenoplate microplates (HCS)