Objective

The highly dynamic post-transcriptional modification of RNA is involved in many regulatory cellular processes and the enzymes that control these changes represent an untapped set of drug targets. While it is possible to monitor RNA modifications indirectly using antibodies and various sequencing approaches, only mass spectrometry can give direct, quantifiable evidence of what chemical changes are occurring. At STORM Therapeutics we have established a mass spectrometry platform that precisely quantifies over 50 different nucleosides and we have also placed some of these chemical changes into their sequence context. It is envisaged that using these technologies, we will be able to gain a more complete understanding of the in vivo function of RNA modifications.