Post-translational modifications on histone tails are important in epigenetic regulation of gene expression. N-methylation on histone lysine residues is removed by histone demethylases (KDMs), an enzyme family which are current medicinal targets. This talk will give an overview of our recent inhibitor development efforts for this family of enzymes, including new strategies used to develop potent and selective peptide inhibitors for the KDM4A-C.
The European Laboratory Research & Innovation Group
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