Objective

Jmjd6 is a highly controversial member of the JmjC sub-family of Fe(II) and 2-oxoglutarate (2OG) dioxygenases.¹ Jmjd6 was first assigned as the phosphatidylserine receptor (PTDSR) which plays a key role in apoptosis by Fadok et al. in 2000.² Thisassignment was challenged when Jmjd6 was subsequently found to be nuclear protein and a 2OG oxygenase.³ Jmjd6 is reported to catalyse lysyl-5 hydroxylation of splicing regulatory factors and other proteins including histones.