Authors

Discussion

Giardia intestinalis (G.I) is an anaerobic protozoa and agent of giardiasis, an infection that induces a loss of epithelial barrier function and functional injuries of the enterocyte, producing diarrhoea and other symptoms. Recently, microvesicles (MVs) have been widely detected in various biological fluids and eukaryotic cells. We have seen a high production of MVs from G.I. trophozoites in response to different environmental conditions during the course of infection.MVs from G.I. alter the proliferation and integrity of Caco cells releasing some virulent factors and miRNA MVs were also  internalized by human immature dendritic cells (iDCs) leading iDCs activation. Functionally, MVs from Giardia intestinalis could modulate innate immunity and host cell interaction.