Research and Innovation 2023 – Accelerating future drug discovery

Presentation

Wednesday 29 March

30 March

[Schedule with Sessions only]

DAY 1

Auditorium

The Rosalind Franklin Room

DAY 2

All times shown are British Summer Time (GMT+1) —

DAY 1

Auditorium

The Rosalind Franklin Room

DAY 2

08:00

08:05

08:10

08:15

08:20

08:25

08:30

Registration and Coffee

08:30

08:35

08:40

08:45

08:50

08:55

09:00

09:05

09:10

09:15

09:20

09:25

09:30

Research and Innovation 2023 – Accelerating future drug discovery

Chairs: Roger Clark, Charles River Labs Saleha Patel, AstraZeneca

ELRIG Event Welcome
09:30 (5 mins)
Melanie Leveridge, GSK

Conference Welcome and Keynote Introduction
09:35 (5 mins)
Saleha Patel, AstraZeneca Roger Clark, Charles River Labs

Mammalian synthetic biology and programmable organoids
09:40 (45 mins)
Ron Weiss, Massachusetts Institute of Technology

09:30

09:35

09:40

09:45

09:50

09:55

10:00

10:05

10:10

10:15

10:20

10:25

Refreshment Break

10:25

10:30

10:35

10:40

10:45

10:50

10:55

11:00

Synthetic biology: genetically programmed healthcare

Chairs: Ron Weiss, Massachusetts Institute of Technology Simon Todd, AstraZeneca

Session Introduction
11:00 (10 mins)
Simon Todd, AstraZeneca Ron Weiss, Massachusetts Institute of Technology

Utilizing synthetic biology to advance therapeutics
11:10 (30 mins)
Tara Deans, University of Utah

Engineering artificial signaling networks in human cells
11:40 (30 mins)
Caleb Bashor, William Marshall Rice University

Ultra-rare disease drug discovery and personalized therapies

Chairs: Joanne Hackett, IQVIA David Fischer, Charles River

Session Introduction
11:00 (10 mins)
Joanne Hackett, IQVIA David Fischer, Charles River

Novel therapies in developmental and epileptic encephalopathies
11:10 (30 mins)
Amy McTague, UCL

Using patient data to enable drug discovery in rare diseases
11:40 (30 mins)
Guido Hartmann, Centogene

11:00

11:05

11:10

11:15

11:20

11:25

11:30

11:35

11:40

11:45

11:50

11:55

12:00

12:05

12:10

CoSolve sustainability live pitching event - Novel solutions to enable organic solvent recycling from R&D processes

Chairs: Kelly Gray, Emerging Innovations Unit, AstraZeneca

Introduction
12:10 (15 mins)
Maurits van Tol, Johnson Matthey

CoSolve Finalist Presentation - Green solvents and solutions for solvent recycling
12:25 (10 mins)
Vesna Najdanovic, Aston University

CoSolve Finalist Presentation - A novel nitrogen assisted method for acetonitrile recovery from HPLC
12:35 (10 mins)
Nenko Nenov, InnoSolv LLC

CoSolve Finalist Presentation - Purification and recovery of organic solvents with membrane technology
12:45 (10 mins)
Sara Salvador Cob, VITO

12:10

12:15

12:20

12:25

12:30

12:35

12:40

12:45

12:50

12:55

13:00

Refreshment Break - Poster Session 13.30 - 14.00

13:00

13:05

13:10

13:15

13:20

13:25

13:30

13:35

13:40

13:45

13:50

13:55

14:00

Synthetic biology: genetically programmed healthcare

Chairs: Ron Weiss, Massachusetts Institute of Technology Simon Todd, AstraZeneca

Steering cellular phenotypes using mathematical modelling and feedback control
14:00 (30 mins)
Lucia Marucci, University of Bristol

High-Throughput Plasmid Purification on the CyBio FeliX Liquid Handler
14:30 (5 mins)
Muji Shah — Promega UK Ltd

BMG LABTECH - microplate reader specialists, introduce keeping cool as a way to enhance assay stability!
14:35 (5 mins)
Catherine Wark — BMG LABTECH Ltd

Learning to program patterning and morphogenesis with synthetic genetic circuits
14:40 (30 mins)
Leonardo Morsut, University of Southern California

Poster Presentation
15:10 (10 mins)
Poster Presentation,

Ultra-rare disease drug discovery and personalized therapies

Chairs: Joanne Hackett, IQVIA David Fischer, Charles River

Realising the benefit to healthcare through population-wide application of polygenic risk scores
14:00 (30 mins)
Gilean McVean, Genomics plc

Advanced spectral cell sorting solutions for immune monitoring and cell purification
14:30 (5 mins)
Katrina Kidd — Cytek Bio

3-D patient-derived models of rare cancers
14:35 (5 mins)
Rebecca Charlton — LGC - ATCC

Development of antisense oligonucleotide therapeutics for the treatment of TUBB4A-related leukodystrophies
14:40 (30 mins)
Laure Humbert, SynaptixBio

SLC transporters and drug discovery: unlocking the "gatekeepers" as therapeutic targets for rare diseases
15:10 (10 mins)
Lucia Azzollini, Axxam Spa

14:00

14:05

14:10

14:15

14:20

14:25

14:30

14:35

14:40

14:45

14:50

14:55

15:00

15:05

15:10

15:15

15:20

Refreshment Break

15:20

15:25

15:30

15:35

15:40

15:45

15:50

Synthetic biology: genetically programmed healthcare

Chairs: Ron Weiss, Massachusetts Institute of Technology Simon Todd, AstraZeneca

Development of compact gene control tools using high-throughput measurements
15:50 (30 mins)
Lacra Bintu, Stanford University

Oxford Nanopore Technologies - a look into the complete genome
16:20 (15 mins)
Rachel Hipkin — Oxford Nanopore Technologies

Epigenome Engineering, Synthetic Immunotherapy, and Better Cell Therapy
16:35 (30 mins)
Lei Stanley Qi, Stanford University

Ultra-rare disease drug discovery and personalized therapies

Chairs: Joanne Hackett, IQVIA David Fischer, Charles River

AI augmented Target Discovery
15:50 (30 mins)
Anne Phelan, BenevolentAI

Cell and Gene Therapy: the ddPCR Solution
16:20 (15 mins)
Jose Martins — Bio-Rad

Nonclinical Development for Rare/Ultra-rare diseases; a Balance of Safety Assessment and High Need
16:35 (30 mins)
Michael Templin, Charles River Laboratories

15:50

15:55

16:00

16:05

16:10

16:15

16:20

16:25

16:30

16:35

16:40

16:45

16:50

16:55

17:00

17:05

Networking Event with Poster Session - 17.30 - 18.00

17:05

17:10

17:15

17:20

17:25

17:30

17:35

17:40

17:45

17:50

17:55

18:00

18:05

18:10

18:15

18:20

18:25

18:30

18:35

18:40

18:45

18:50

18:55

19:00