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Presentation
9 November
Wednesday 10 November
DAY 1
AuditoriumHelix RoomDAY 2
All times shown are GMT —
DAY 1
AuditoriumHelix RoomDAY 2
08:00 08:00
08:05 08:05
08:10 08:10
08:15 08:15
08:20 08:20
08:25 08:25
08:30 Event Registration 08:30
08:35 08:35
08:40 08:40
08:45 08:45
08:50 08:50
08:55 08:55
09:00
Conference Welcome and Plenary Keynote Introduction
Chair:
Discussant:
Chairs: Jarrod Walsh, AstraZeneca  Gareth Davies, AstraZeneca  Finn Holding, Astrazeneca  David Cronk, Domainex Ltd  
09:00
09:05 09:05
09:10
Keynote Presentation
Chair:
Discussant:
09:10
09:15 09:15
09:20 09:20
09:25 09:25
09:30 09:30
09:35 09:35
09:40 09:40
09:45 09:45
09:50 09:50
09:55 09:55
10:00 Refreshment Break 10:00
10:05 10:05
10:10 10:10
10:15 10:15
10:20 10:20
10:25 10:25
10:30
Emerging Discovery Strategies
Chair:
Discussant:
Chairs: Peter Coombs, LifeArc  Kirsten Tschapalda, Roche  

Modernising Drug Design and Prioritisation with AI
10:30 (30 mins)
Simon Richards, Exscientia  

Getting started with high-throughput mass spectrometry in early drug discovery
11:00 (30 mins)
Martin Bachman, Medicines Discovery Catapult  

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins
11:30 (30 mins)
Adam Bond, Centre for Targeted Protein Degradation (CeTPD), University of Dundee   
MS & Biophysical Approaches in Early Drug Discovery
Chair:
Discussant:
Chairs: Geoff Holdgate, AstraZeneca  Trevor Askwith, Domainex  

Building a high-throughput MS workflow for covalent Hit Finding
10:30 (30 mins)
Sarah Hewitt, AstraZeneca  

Utilizing biophysics to kick start drug discovery projects
11:00 (15 mins)
Jana Wolf, Domainex  

MALDI-TOF AS-MS – a label-free hit validation strategy in early drug discovery
11:15 (15 mins)
Roman Simon, Boehringer Ingelheim Pharma GmbH & Co. KG  
10:30
10:35 10:35
10:40 10:40
10:45 10:45
10:50 10:50
10:55 10:55
11:00 11:00
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11:45 11:45
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11:55 11:55
12:00 12:00
12:05 Refreshment Break 12:05
12:10 12:10
12:15 12:15
12:20 12:20
12:25 12:25
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12:35 12:35
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12:55 12:55
13:00 13:00
13:05 13:05
13:10 13:10
13:15 13:15
13:20 13:20
13:25 13:25
13:30
Emerging Discovery Strategies
Chair:
Discussant:
Chairs: Peter Coombs, LifeArc  Kirsten Tschapalda, Roche  

Accelerating the validation of endogenous on-target engagement and assessment of in-cellulo kinetics for covalent inhibitors in early drug discovery
13:30 (30 mins)
Vasudev Kantae, AstraZeneca  

New way of screening: A case study comparing an iterative screening approach to conventional HTS campaigns.
14:00 (30 mins)
Markus Hierl, Hoffmann La Roche  

A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia
14:30 (30 mins)
Matthias Trost, Newcastle University  
MS & Biophysical Approaches in Early Drug Discovery
Chair:
Discussant:
Chairs: Geoff Holdgate, AstraZeneca  Trevor Askwith, Domainex  

Revolutionizing Screening: MALDI-ToF Mass Spectrometry in a Fully Automated HTS System
13:30 (30 mins)
Steven van Helden, Pivot Park Screening Centre  

Reactive fragment screening for expansion of the liganded proteome
14:00 (30 mins)
Jacob Bush, GlaxoSmithKline  

Identification of allosteric binders of an active GPCR : Screening of EDELRIS Keymical Space™ by Affinity Selection-Mass Spectrometry
14:30 (30 mins)
Renaud Prudent, EDELRIS  
13:30
13:35 13:35
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13:55 13:55
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14:55 14:55
15:00
Conference Close and Awards
Chair:
Discussant:
Chairs: David Cronk, Domainex Ltd  
15:00
15:05 15:05
15:10 15:10
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19:00 19:00