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Discovery Technologies 2021
Tuesday, 9 November 2021 to Wednesday, 10 November 2021
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Presentation
Tuesday 9 November
10 November
[Schedule with Sessions only]
DAY 1AuditoriumHelix Room
DAY 2
All times shown are GMT
DAY 1AuditoriumHelix Room
DAY 2
08:00 08:00
08:05 08:05
08:10 08:10
08:15 08:15
08:20 08:20
08:25 08:25
08:30 Event Registration 08:30
08:35 08:35
08:40 08:40
08:45 08:45
08:50 08:50
08:55 08:55
09:00 09:00
09:05 09:05
09:10 09:10
09:15 Alderley Park Site Welcome
Chairs: Kath Mackay
 09:15
09:20 Conference Welcome and Plenary Keynote Introduction
Chairs: Jarrod Walsh, AstraZeneca  
 09:20
09:25 Keynote Presentation
YouTube
Advances in Phenomics Drug Discovery: Combining high content and pathway profiling technologies with multiparametric data analysis tools to discover novel and effective drug mechanisms-of-action.
09:25 (50 mins)
Prof Neil Carragher, University of Edinburgh  
YouTube
Bioluminescent Tools & Approaches for RAS Pathway Drug Discovery
10:15 (15 mins)
Dr Craig Malcolm — Promega UK Ltd  
 09:25
09:30 09:30
09:35 09:35
09:40 09:40
09:45 09:45
09:50 09:50
09:55 09:55
10:00 10:00
10:05 10:05
10:10 10:10
10:15 10:15
10:20 10:20
10:25 10:25
10:30 Refreshment Break 10:30
10:35 10:35
10:40 10:40
10:45 10:45
10:50 10:50
10:55 10:55
11:00 11:00
11:05 11:05
11:10 11:10
11:15 Emerging Discovery Strategies
Chairs: Dr Emily Offer, Medicines Discovery Catapult  Dr Graeme Walker, Sygnature Discovery  
YouTube
An update on the JUMP-CP Consortium: insights from pilot experiments and outlook
11:15 (30 mins)
Paula A. Marin-Zapata, Bayer  
R&D at the New Speed of Science - Accelerate your R&D Transformation with Benchling
11:45 (5 mins)
Jonathan Stone — Benchling  
YouTube
From Theraphosid to Therapy: Screening a venom library using high-throughput automated patch clamp to identify novel and selective sodium channel modulators
11:50 (30 mins)
Miss Elaine Duncan, Charles River   Steven Trim, Venomtech Ltd  
 Hit Triage
Chairs: Dr Gareth Davies, AstraZeneca  Dr Kirsty Winn, Medicines Discovery Catapult  
YouTube
Application of Acoustic Mist Ionisation MS to rapidly identify hits with undesirable mechanisms of action in HTS outputs
11:15 (30 mins)
Dr Rachel Moore, AstraZeneca  
YouTube
Assist Plus
11:45 (5 mins)
Ms Sharon Barnard — INTEGRA Biosciences  
YouTube
Case studies in cellular nuisance compounds
11:50 (30 mins)
Dr Jayme Dahlin, National Center for Advancing Translational Science (NCATS)  
 11:15
11:20 11:20
11:25 11:25
11:30 11:30
11:35 11:35
11:40 11:40
11:45 11:45
11:50 11:50
11:55 11:55
12:00 12:00
12:05 12:05
12:10 12:10
12:15 12:15
12:20 12:20
12:25 Refreshment Break 12:25
12:30 12:30
12:35 12:35
12:40 12:40
12:45 12:45
12:50 12:50
12:55 12:55
13:00 13:00
13:05 13:05
13:10 13:10
13:15 13:15
13:20 13:20
13:25 13:25
13:30 13:30
13:35 13:35
13:40 13:40
13:45 13:45
13:50 13:50
13:55 13:55
14:00 Emerging Discovery Strategies
Chairs: Dr Emily Offer, Medicines Discovery Catapult  Dr Graeme Walker, Sygnature Discovery  
YouTube
Fragment-based screening coupled to chemical proteomics as an emerging paradigm for early drug discovery in ER+ breast cancer
14:00 (30 mins)
Dr Stephanie Constantinou, AstraZeneca  Dr Aarti Kawatkar, AstraZeneca  
YouTube
CDD Vault - Complexity Simplified
14:30 (5 mins)
Miss Tamsin Lamont — Collaborative Drug Discovery  
YouTube
The concept of G-quadruplex ligands as novel gene regulators and potential anticancer drugs
14:35 (30 mins)
Stephen Neidle, UCL School of Pharmacy  
 Hit Triage
Chairs: Dr Gareth Davies, AstraZeneca  Dr Kirsty Winn, Medicines Discovery Catapult  
YouTube
Developing assay development tools to make screening less PAINS-full
14:00 (30 mins)
Dr Stuart McElroy, BioAscent Discovery ltd.  
YouTube
An Introduction of the Medicines Discovery Catapult
14:30 (5 mins)
Dr Martin Main — Medicines Discovery Catapult  
Computational and Empirical Strategies to Triage Nuisance Compounds in HTS
14:35 (30 mins)
Sarah Martin, Charles River   Scott Maidment, Charles River  
 14:00
14:05 14:05
14:10 14:10
14:15 14:15
14:20 14:20
14:25 14:25
14:30 14:30
14:35 14:35
14:40 14:40
14:45 14:45
14:50 14:50
14:55 14:55
15:00 15:00
15:05 Refreshment Break 15:05
15:10 15:10
15:15 15:15
15:20 15:20
15:25 15:25
15:30 15:30
15:35 Emerging Discovery Strategies
Chairs: Dr Emily Offer, Medicines Discovery Catapult  Dr Graeme Walker, Sygnature Discovery  
Right assay, right hit, right time. Identify “more physiological hits” earlier in drug discovery
15:35 (30 mins)
Mrs Kathy Dodgson, Aurelia Bioscience Ltd  
YouTube
Patient-derived cell models as a clinically-relevant drug discovery strategy
16:05 (30 mins)
Gareth Griffiths, Imagen Therapeutics  
 Hit Triage
Chairs: Dr Gareth Davies, AstraZeneca  Dr Kirsty Winn, Medicines Discovery Catapult  
YouTube
Hit or Miss? The Importance of Triage in the Active to Hit Transition
15:35 (30 mins)
Alexandra Stowell, Sygnature Discovery  
YouTube
Pragmatic screening collection refinement to facilitate hit progression
16:05 (30 mins)
Dr Kristian Birchall, LifeArc  
 15:35
15:40 15:40
15:45 15:45
15:50 15:50
15:55 15:55
16:00 16:00
16:05 16:05
16:10 16:10
16:15 16:15
16:20 16:20
16:25 16:25
16:30 16:30
16:35 Networking Event 16:35
16:40 16:40
16:45 16:45
16:50 16:50
16:55 16:55
17:00 17:00
17:05 17:05
17:10 17:10
17:15 17:15
17:20 17:20
17:25 17:25
17:30 17:30
17:35 17:35
17:40 17:40
17:45 17:45
17:50 17:50
17:55 17:55
18:00 18:00
18:05 18:05
18:10 18:10
18:15 18:15
18:20 18:20
18:25 18:25
18:30 18:30
18:35 18:35
18:40 18:40
18:45 18:45
18:50 18:50
18:55 18:55
19:00 19:00