Dr Jan Kihlberg

Professor Jan Kihlberg holds a chair in Organic Chemistry at Uppsala University, Sweden since 2013. His key research interest is to understand what properties convey cell permeability, aqueous solubility and target binding to drugs in the beyond rule of 5 space and to translate this knowledge into guidelines for design. His group has a particular interest in the structure-property relationships of macrocycles and proteolysis targeting chimeras (PROTACs). It is also involved in synthesis of macrocycles originating from natural products as ligands for difficult-to-drug targets. He has published 172 peer reviewed articles, 18 research reviews and four book chapters. Before moving to Uppsala Prof. Kihlberg spent ten years at AstraZeneca R&D in Gothenburg, seven of which as Director of Medicinal Chemistry. He obtained his PhD in organic chemistry at Lund University in 1988.