Tuesday, 9 November 2021 to Wednesday, 10 November 2021
| Getting started with high-throughput mass spectrometry in early drug discovery | |||||
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Wed10 Nov11:00am(30 mins)
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Dr Martin Bachman | |||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Assist Plus | |||||
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Tue9 Nov11:45am(5 mins)
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Ms Sharon Barnard | ||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| Using DiBT-MS for high throughput and novel biocatalyst pharmaceutical discovery | |||||
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Wed10 Nov09:10am(50 mins)
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Perdita Barran | ||
| Session : Keynote Presentation | |||||
| Room: Auditorium | |||||
| Pragmatic screening collection refinement to facilitate hit progression | |||||
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Tue9 Nov04:05pm(30 mins)
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Dr Kristian Birchall | ||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| Reactive fragment screening for expansion of the liganded proteome | |||||
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Wed10 Nov02:00pm(30 mins)
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Jacob Bush | ||
| Session : MS & Biophysical Approaches in Early Drug Discovery | |||||
| Room: Helix Room | |||||
| Case studies in cellular nuisance compounds | |||||
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Tue9 Nov11:50am(30 mins)
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Dr Jayme Dahlin | ||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| Right assay, right hit, right time. Identify “more physiological hits” earlier in drug discovery | |||||
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Tue9 Nov03:35pm(30 mins)
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Mrs Kathy Dodgson | |||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Patient-derived cell models as a clinically-relevant drug discovery strategy | |||||
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Tue9 Nov04:05pm(30 mins)
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Gareth Griffiths | ||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Building a high-throughput MS workflow for covalent Hit Finding | |||||
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Wed10 Nov10:30am(30 mins)
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Dr Sarah Hewitt | |||
| Session : MS & Biophysical Approaches in Early Drug Discovery | |||||
| Room: Helix Room | |||||
| New way of screening: A case study comparing an iterative screening approach to conventional HTS campaigns. | |||||
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Wed10 Nov02:00pm(30 mins)
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Markus Hierl | ||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| CDD Vault - Complexity Simplified | |||||
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Tue9 Nov02:30pm(5 mins)
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Miss Tamsin Lamont | ||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Computational and Empirical Strategies to Triage Nuisance Compounds in HTS | |||||
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Tue9 Nov02:35pm(30 mins)
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Scott Maidment | |||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| An Introduction of the Medicines Discovery Catapult | |||||
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Tue9 Nov02:30pm(5 mins)
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Dr Martin Main | ||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| Bioluminescent Tools & Approaches for RAS Pathway Drug Discovery | |||||
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Tue9 Nov10:15am(15 mins)
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Dr Craig Malcolm | ||
| Session : Keynote Presentation | |||||
| Room: Auditorium | |||||
| An update on the JUMP-CP Consortium: insights from pilot experiments and outlook | |||||
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Tue9 Nov11:15am(30 mins)
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Paula A. Marin-Zapata | ||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Computational and Empirical Strategies to Triage Nuisance Compounds in HTS | |||||
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Tue9 Nov02:35pm(30 mins)
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Sarah Martin | |||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| Developing assay development tools to make screening less PAINS-full | |||||
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Tue9 Nov02:00pm(30 mins)
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Dr Stuart McElroy | ||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| Application of Acoustic Mist Ionisation MS to rapidly identify hits with undesirable mechanisms of action in HTS outputs | |||||
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Tue9 Nov11:15am(30 mins)
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Dr Rachel Moore | ||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| The concept of G-quadruplex ligands as novel gene regulators and potential anticancer drugs | |||||
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Tue9 Nov02:35pm(30 mins)
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Stephen Neidle | ||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Modernising Drug Design and Prioritisation with AI | |||||
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Wed10 Nov10:30am(30 mins)
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Simon Richards | |||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| MALDI-TOF AS-MS – a label-free hit validation strategy in early drug discovery | |||||
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Wed10 Nov11:15am(15 mins)
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Dr Roman Simon | ||
| Session : MS & Biophysical Approaches in Early Drug Discovery | |||||
| Room: Helix Room | |||||
| R&D at the New Speed of Science - Accelerate your R&D Transformation with Benchling | |||||
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Tue9 Nov11:45am(5 mins)
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Jonathan Stone | |||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Hit or Miss? The Importance of Triage in the Active to Hit Transition | |||||
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Tue9 Nov03:35pm(30 mins)
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Alexandra Stowell | ||
| Session : Hit Triage | |||||
| Room: Helix Room | |||||
| A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia | |||||
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Wed10 Nov02:30pm(30 mins)
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Prof Matthias Trost | ||
| Session : Emerging Discovery Strategies | |||||
| Room: Auditorium | |||||
| Revolutionizing Screening: MALDI-ToF Mass Spectrometry in a Fully Automated HTS System | |||||
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Wed10 Nov01:30pm(30 mins)
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Dr Steven van Helden | ||
| Session : MS & Biophysical Approaches in Early Drug Discovery | |||||
| Room: Helix Room | |||||
| Utilizing biophysics to kick start drug discovery projects | |||||
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Wed10 Nov11:00am(15 mins)
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Dr Jana Wolf | ||
| Session : MS & Biophysical Approaches in Early Drug Discovery | |||||
| Room: Helix Room | |||||
