Research and Innovation 2023 – Accelerating future drug discovery

Presentation

Wed 29 March

30 March

[Schedule with Sessions only]

DAY 1

Auditorium

The Rosalind Franklin Room

DAY 2

DAY 1

Auditorium

The Rosalind Franklin Room

DAY 2

8:00

8:00:

8:05:

8:10:

8:15:

8:20:

8:25:

8:30:

Registration and Coffee

8:30:

8:35:

8:40:

8:45:

8:50:

8:55:

9:00

9:00:

9:05:

9:10:

9:15:

9:20:

9:25:

9:30:

Research and Innovation 2023 – Accelerating future drug discovery

Chairs: Roger Clark, Charles River Labs Saleha Patel, AstraZeneca

ELRIG Event Welcome
09:30 (5 mins)
Melanie Leveridge, GSK

Conference Welcome and Keynote Introduction
09:35 (5 mins)
Saleha Patel, AstraZeneca Roger Clark, Charles River Labs

Mammalian synthetic biology and programmable organoids
09:40 (45 mins)
Ron Weiss, Massachusetts Institute of Technology

9:30:

9:35:

9:40:

9:45:

9:50:

9:55:

10:00

10:05

10:10

10:15

10:20

10:25

Refreshment Break

10:25

10:30

10:35

10:40

10:45

10:50

10:55

11:00

Synthetic biology: genetically programmed healthcare

Chairs: Ron Weiss, Massachusetts Institute of Technology Simon Todd, AstraZeneca

Session Introduction
11:00 (10 mins)
Simon Todd, AstraZeneca Ron Weiss, Massachusetts Institute of Technology

Utilizing synthetic biology to advance therapeutics
11:10 (30 mins)
Tara Deans, University of Utah

Engineering artificial signaling networks in human cells
11:40 (30 mins)
Caleb Bashor, William Marshall Rice University

Ultra-rare disease drug discovery and personalized therapies

Chairs: Joanne Hackett, IQVIA David Fischer, Charles River

Session Introduction
11:00 (10 mins)
Joanne Hackett, IQVIA David Fischer, Charles River

Novel therapies in developmental and epileptic encephalopathies
11:10 (30 mins)
Amy McTague, UCL

Using patient data to enable drug discovery in rare diseases
11:40 (30 mins)
Guido Hartmann, Centogene

11:00

11:05

11:10

11:15

11:20

11:25

11:30

11:35

11:40

11:45

11:50

11:55

12:00

12:05

12:10

CoSolve sustainability live pitching event - Novel solutions to enable organic solvent recycling from R&D processes

Chairs: Kelly Gray, Emerging Innovations Unit, AstraZeneca

Introduction
12:10 (15 mins)
Maurits van Tol, Johnson Matthey

CoSolve Finalist Presentation - Green solvents and solutions for solvent recycling
12:25 (10 mins)
Vesna Najdanovic, Aston University

CoSolve Finalist Presentation - A novel nitrogen assisted method for acetonitrile recovery from HPLC
12:35 (10 mins)
Nenko Nenov, InnoSolv LLC

CoSolve Finalist Presentation - Purification and recovery of organic solvents with membrane technology
12:45 (10 mins)
Sara Salvador Cob, VITO

12:10

12:15

12:20

12:25

12:30

12:35

12:40

12:45

12:50

12:55

1:00

Refreshment Break - Poster Session 13.30 - 14.00

1:00:

1:05:

1:10:

1:15:

1:20:

1:25:

1:30:

1:35:

1:40:

1:45:

1:50:

1:55:

2:00

Synthetic biology: genetically programmed healthcare

Chairs: Ron Weiss, Massachusetts Institute of Technology Simon Todd, AstraZeneca

Steering cellular phenotypes using mathematical modelling and feedback control
14:00 (30 mins)
Lucia Marucci, University of Bristol

High-Throughput Plasmid Purification on the CyBio FeliX Liquid Handler
14:30 (5 mins)
Muji Shah — Promega UK Ltd

BMG LABTECH - microplate reader specialists, introduce keeping cool as a way to enhance assay stability!
14:35 (5 mins)
Catherine Wark — BMG LABTECH Ltd

Learning to program patterning and morphogenesis with synthetic genetic circuits
14:40 (30 mins)
Leonardo Morsut, University of Southern California

Poster Presentation
15:10 (10 mins)
Poster Presentation,

Ultra-rare disease drug discovery and personalized therapies

Chairs: Joanne Hackett, IQVIA David Fischer, Charles River

Realising the benefit to healthcare through population-wide application of polygenic risk scores
14:00 (30 mins)
Gilean McVean, Genomics plc

Advanced spectral cell sorting solutions for immune monitoring and cell purification
14:30 (5 mins)
Katrina Kidd — Cytek Bio

3-D patient-derived models of rare cancers
14:35 (5 mins)
Rebecca Charlton — LGC - ATCC

Development of antisense oligonucleotide therapeutics for the treatment of TUBB4A-related leukodystrophies
14:40 (30 mins)
Laure Humbert, SynaptixBio

SLC transporters and drug discovery: unlocking the "gatekeepers" as therapeutic targets for rare diseases
15:10 (10 mins)
Lucia Azzollini, Axxam Spa

2:00:

2:05:

2:10:

2:15:

2:20:

2:25:

2:30:

2:35:

2:40:

2:45:

2:50:

2:55:

3:00

3:00:

3:05:

3:10:

3:15:

3:20:

Refreshment Break

3:20:

3:25:

3:30:

3:35:

3:40:

3:45:

3:50:

Synthetic biology: genetically programmed healthcare

Chairs: Ron Weiss, Massachusetts Institute of Technology Simon Todd, AstraZeneca

Development of compact gene control tools using high-throughput measurements
15:50 (30 mins)
Lacra Bintu, Stanford University

Oxford Nanopore Technologies - a look into the complete genome
16:20 (15 mins)
Rachel Hipkin — Oxford Nanopore Technologies

Epigenome Engineering, Synthetic Immunotherapy, and Better Cell Therapy
16:35 (30 mins)
Lei Stanley Qi, Stanford University

Ultra-rare disease drug discovery and personalized therapies

Chairs: Joanne Hackett, IQVIA David Fischer, Charles River

AI augmented Target Discovery
15:50 (30 mins)
Anne Phelan, BenevolentAI

Cell and Gene Therapy: the ddPCR Solution
16:20 (15 mins)
Jose Martins — Bio-Rad

Nonclinical Development for Rare/Ultra-rare diseases; a Balance of Safety Assessment and High Need
16:35 (30 mins)
Michael Templin, Charles River Laboratories

3:50:

3:55:

4:00

4:00:

4:05:

4:10:

4:15:

4:20:

4:25:

4:30:

4:35:

4:40:

4:45:

4:50:

4:55:

5:00

5:00:

5:05:

Networking Event with Poster Session - 17.30 - 18.00

5:05:

5:10:

5:15:

5:20:

5:25:

5:30:

5:35:

5:40:

5:45:

5:50:

5:55:

6:00

6:00:

6:05:

6:10:

6:15:

6:20:

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6:30:

6:35:

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6:50:

6:55:

7:00

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