Protein Sciences in Drug Discovery 2022
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Presentation
Wed 2 November
3 November
[Schedule with Sessions only]
DAY 1The Auditorium
DAY 2
DAY 1The Auditorium
DAY 2
8:00 8:00:
8:05: 8:05:
8:10: 8:10:
8:15: 8:15:
8:20: 8:20:
8:25: 8:25:
8:30: Registration
08:30 (60 mins)
 8:30:
8:35: 8:35:
8:40: 8:40:
8:45: 8:45:
8:50: 8:50:
8:55: 8:55:
9:00 9:00:
9:05: 9:05:
9:10: 9:10:
9:15: 9:15:
9:20: 9:20:
9:25: 9:25:
9:30:
Conference Welcome
Chairs: Lovisa Holmberg Schiavone, AstraZeneca  Theresia Schaedler, Maxion Therapeutics  Kate Smith, GlaxoSmithKline  
 9:30:
9:35: 9:35:
9:40:
High-throughput approaches for protein expression
Chairs: Hanna Tegel, Royal Institute of Technology (KTH)  Helena Firczuk, GSK  
Session Introduction
09:40 (5 mins)
Hanna Tegel, Royal Institute of Technology (KTH)  Helena Firczuk, GSK  
High-Throughput Protein Expression
09:45 (30 mins)
Nicola Burgess-Brown, Exact Sciences Innovation Ltd.  
Services and Tools for Protein Analysis: How Bio-Rad Can Boost Your Drug Discovery Workflow
10:15 (15 mins)
Richard Cuthbert — Bio-Rad    
 9:40:
9:45: 9:45:
9:50: 9:50:
9:55: 9:55:
10:00 10:00
10:05 10:05
10:10 10:10
10:15 10:15
10:20 10:20
10:25 10:25
10:30 Refreshment Break 10:30
10:35 10:35
10:40 10:40
10:45 10:45
10:50 10:50
10:55 10:55
11:00 11:00
11:05 11:05
11:10 11:10
11:15
High-throughput approaches for protein expression
Chairs: Helena Firczuk, GSK  Hanna Tegel, Royal Institute of Technology (KTH)  
A high-throughput parallel protein workflow to accelerate antimicrobial drug discovery at LifeArc
11:15 (30 mins)
Peter Canning, LifeArc  
Automated assay for quantification of antibody titre in crude samples
11:45 (5 mins)
Ruizhi Wang — HexagonFab    
ASSIST Plus Pipetting Platform
11:50 (5 mins)
Kiran Sharma — INTEGRA Bioscience Ltd    
Accelerating Drug Discovery: A Refresh of the Lead Panel Generation Phase within Biopharm Discovery
11:55 (30 mins)
Edward Coulstock, GlaxoSmithKline  
Production of Cas9 orthologs for functional and structural studies
12:25 (15 mins)
Thomas Meins — WuXi AppTec    
 11:15
11:20 11:20
11:25 11:25
11:30 11:30
11:35 11:35
11:40 11:40
11:45 11:45
11:50 11:50
11:55 11:55
12:00 12:00
12:05 12:05
12:10 12:10
12:15 12:15
12:20 12:20
12:25 12:25
12:30 12:30
12:35 12:35
12:40 Refreshment Break with Poster Session 13.30 - 14.00 12:40
12:45 12:45
12:50 12:50
12:55 12:55
1:00 1:00:
1:05: 1:05:
1:10: 1:10:
1:15: 1:15:
1:20: 1:20:
1:25: 1:25:
1:30: 1:30:
1:35: 1:35:
1:40: 1:40:
1:45: 1:45:
1:50: 1:50:
1:55: 1:55:
2:00
Advancement in protein production of novel and challenging soluble targets
Chairs: Panchali Goswami, GlaxoSmithKline  Valerie Pye, Francis Crick Institute  
Session Introduction
14:00 (5 mins)
Valerie Pye, Francis Crick Institute  Panchali Goswami, GlaxoSmithKline  
Investigating epigenetics using electron microscopy (and a little bit of Chemistry)
14:05 (30 mins)
Marcus Wilson, University of Edinburgh  
Enhance your separation power and increase product purity with the J.T.Baker® BAKERBOND® PROchievA™ protein A derived affinity chromatography resin
14:35 (5 mins)
Meera Pirie — Avantor    
 2:00:
2:05: 2:05:
2:10: 2:10:
2:15: 2:15:
2:20: 2:20:
2:25: 2:25:
2:30: 2:30:
2:35: 2:35:
2:40:
Poster Presentations
Poster Presentation Introductions
14:40 (5 mins)
Theresia Schaedler, Maxion Therapeutics  
‘SNARE Proteins’-Maximizing Protein Expression in Mammalian Cells.
14:45 (10 mins)
Angita Shrestha, GSK  
A novel screening platform to monitor GPCR-G proteins complex formation
14:55 (10 mins)
William Lee, AstraZeneca  
 2:40:
2:45: 2:45:
2:50: 2:50:
2:55: 2:55:
3:00 3:00:
3:05: Refreshment Break 3:05:
3:10: 3:10:
3:15: 3:15:
3:20: 3:20:
3:25: 3:25:
3:30: 3:30:
3:35: 3:35:
3:40:
Advancement in protein production of novel and challenging soluble targets
Chairs: Panchali Goswami, GlaxoSmithKline  Valerie Pye, Francis Crick Institute  
Exploiting the versatility of synthetic nanobodies in protein production and structural biology
15:40 (30 mins)
Lisa Joedicke, Roche  
Expression and Purification of a Challenging, Disordered Transcription Factor
16:10 (15 mins)
Duncan Smith — Peak Proteins Ltd    
Building the replisome: structure and mechanism of a DNA replication machine
16:25 (30 mins)
Joe Yeeles, MRC Laboratory of Molecular Biology  
 3:40:
3:45: 3:45:
3:50: 3:50:
3:55: 3:55:
4:00 4:00:
4:05: 4:05:
4:10: 4:10:
4:15: 4:15:
4:20: 4:20:
4:25: 4:25:
4:30: 4:30:
4:35: 4:35:
4:40: 4:40:
4:45: 4:45:
4:50: 4:50:
4:55:
Keynote Presentation
Keynote Introduction
16:55 (5 mins)
Lovisa Holmberg Schiavone, AstraZeneca  
Protein design using deep learning
17:00 (45 mins)
David Baker, University of Washington  
 4:55:
5:00 5:00:
5:05: 5:05:
5:10: 5:10:
5:15: 5:15:
5:20: 5:20:
5:25: 5:25:
5:30: 5:30:
5:35: 5:35:
5:40: 5:40:
5:45:
Networking with Poster Session 18.30 - 19.00
 5:45:
5:50: 5:50:
5:55: 5:55:
6:00 6:00:
6:05: 6:05:
6:10: 6:10:
6:15: 6:15:
6:20: 6:20:
6:25: 6:25:
6:30: 6:30:
6:35: 6:35:
6:40: 6:40:
6:45: 6:45:
6:50: 6:50:
6:55: 6:55:
7:00 7:00: