Drug Discovery 2022: driving the next life science revolution

Presentation

Tue 4 October

5 October

[Schedule with Sessions only]

DAY 1

Auditorium 1

Auditorium 2

Auditorium 3

Auditorium 4

DAY 2

DAY 1

Auditorium 1

Auditorium 2

Auditorium 3

Auditorium 4

DAY 2

8:00

Registration

Early Career Professional (ECP) Meet & Greet

8:00:

8:05:

8:10:

8:15:

8:20:

8:25:

8:30:

8:35:

8:40:

8:45:

8:50:

8:55:

9:00

9:00:

9:05:

9:10:

ELRIG Annual Review

Chairs: Catherine Kettleborough, LifeArc, The Accelerator Sanj Kumar, ELRIG

9:10:

9:15:

9:20:

9:25:

9:30:

Conference Welcome and Keynote Introduction

Chairs: Katie Chapman, VC funded Biotech Company Simon Chell, AstraZeneca Jon Hutchinson, GlaxoSmithKline Simon Ward, University of Cardiff

9:30:

9:35:

Keynote Presentation

New technologies for the design and characterisation of nanotechnology mediated therapeutics
09:35 (45 mins)
Molly Stevens, Imperial College London

9:35:

9:40:

9:45:

9:50:

9:55:

10:00

10:05

10:10

10:15

10:20

Refreshment Break

DDW - Taking your first steps towards liquid handling automation - Sponsored by SPT Labtech

Chairs: Anne Hammerstein, SPT Labtech

Langton Howarth- Understanding the needs of talent acquisition departments to start a career in a life-science corporations: Ask an Expert!’

Chairs: Chris Luche, Sanger Institute Sue Ward, Illumina

10:20

10:25

10:30

10:35

10:40

10:45

10:50

10:55

11:00

11:05

High Content Imaging in Drug Discovery

Chairs: Sian Lewis, MSD Michael Howell, The Francis Crick Institute

Session Introduction
11:05 (5 mins)
Sian Lewis, MSD Michael Howell, The Francis Crick Institute

High Content Imaging as an enabling tool for early drug discovery
11:10 (30 mins)
John Bassett, MSD

Patient-Derived Cell (PDC) Models as a Tool to Assess Cancer Therapeutic Efficacy Across the Drug Development Life Cycle
11:40 (30 mins)
Rachel Howard-Jones — Nexcelom from PerkinElmer

Accelerating Drug Discovery with Cell Painting
12:10 (30 mins)
James Pilling, AstraZeneca

Microplate readers and imaging systems
12:40 (5 mins)
Imran Haneef — LabLogic Systems Limited

Overcoming Challenges and New Directions in Medicinal Chemistry

Chairs: Allan Jordan, Sygnature Discovery Sarah Skerrat, CHARM Therapeutics

Session Introduction
11:05 (5 mins)
Allan Jordan, Sygnature Discovery Sarah Skerrat, CHARM Therapeutics

Discovery and validation of in vitro and in vivo probes for human DNA Polymerase theta (Polθ)
11:10 (30 mins)
Robert Heald, Artios Pharma

The COVID Moonshot – from open science collaboration in fragment screening to drug candidate and beyond to Pandemic Preparedness
11:40 (30 mins)
Ed Griffen, MedChemica Ltd

ML/AI: Opportunities, Impact and Future Directions in Drug Design
12:10 (30 mins)
Sarah Skerrat, CHARM Therapeutics

Cell & Gene Therapy Sponsored by Miltenyi

Chairs: Chris Herring, Adaptimmune Claire Dobson, AstraZeneca

Session Introduction
11:05 (5 mins)
Chris Herring, Adaptimmune Claire Dobson, AstraZeneca

TCR Evolution, revolution: How Adaptimmune is developing innovative TCR T-cell therapies to treat solid tumors
11:10 (30 mins)
Jo Brewer, Adaptimmune Limited

The journey from discovery to therapy begins with a single cell
11:40 (30 mins)
Stephen Hague — 10x Genomics

From Stem-Cells to T-Cells: Next-Generation DNA NanoVectors -an Alternative Non-Integrating DNA Vector Platform for Regenerative Medicine and Immunotherapy
12:10 (30 mins)
Richard Harbottle, German Cancer Research Centre (DKFZ)

Automating high-throughput NGS and qPCR assays: Meet the Biomark™ X and the Juno™
12:40 (5 mins)
James Curtis — Standard Bio Tools

Drug Discovery and Development in COPD

Chairs: Anna Morgan, Physiology & Pharmacology, Kingston University Simon Pitchford, King's College London

Session Introduction
11:05 (5 mins)
Anna Morgan, Physiology & Pharmacology, Kingston University Simon Pitchford, King's College London

The burden of unmet needs in COPD
11:10 (30 mins)
Wisia Wedzicha, Imperial College London

Novel drug targets in COPD
11:40 (30 mins)
Ian Adcock, Imperial College London

New perspectives for modelling inflammatory diseases using patient-derived organoids
12:10 (5 mins)
Sylvia F. Boj — HUB Organoids

Use of Imaging for preclinical evaluation of drugs for the treatment of COPD
12:15 (30 mins)
Anna Morgan, Physiology & Pharmacology, Kingston University

11:05

11:10

11:15

11:20

11:25

11:30

11:35

11:40

11:45

11:50

11:55

12:00

12:05

12:10

12:15

12:20

12:25

12:30

12:35

12:40

12:45

Refreshment Break - Poster Session 13.15 - 13.45

DDW - The role of AI and automation in personalised medicine: How can AI help in the post drug discovery process.

Chairs: Yahya Anvar, OKRA.ai

Cytek Bio Workshop - Full Spectrum Profiling (FSP)™, adaptable solutions to deep immunophenotyping using the Cytek Aurora: a practical walkthrough

12:45

12:50

12:55

1:00

1:00:

1:05:

1:10:

1:15:

1:20:

DDW - Data handling and choosing the right informatics systems for your lab requirements - Sponsored by CDD

Chairs: Samantha Kanza, University of Southampton

1:20:

1:25:

1:30:

1:35:

1:40:

1:45:

1:50:

1:55:

2:00

High Content Imaging in Drug Discovery

Phenonaut; a tool for multiomic data integration, analysis, prediction, and inference
14:00 (30 mins)
Steven Shave, University of Edinburgh & GSK

10x Your Lab: High Content Analysis Meets High-Throughput Screening
14:30 (5 mins)
Kristin Halfpenny — Araceli Biosciences

spheroONE – an automated high throughput spheroid isolation and manipulation technology.
14:35 (5 mins)
Alice Cheesbrough — Cellenion

Life beyond the pixels: single-cell analysis using deep learning and image analysis methods
14:40 (30 mins)
Peter Horvath, Biological Research Centre, Szeged

Overcoming Challenges and New Directions in Medicinal Chemistry

Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery - Design tips and tricks
14:00 (30 mins)
Jamie Scott, AstraZeneca

Supporting innovations in Splicesome research
14:30 (5 mins)
ROSLYN McConnell — Avantor

New Approaches to the Synthesis and Application of DNA-Encoded Libraries
14:35 (30 mins)
Jessica Graham, Newcastle University Harriet Stanway-Gordon, Newcastle University

Cell & Gene Therapy Sponsored by Miltenyi

Pin-point™ – A Modular Base Editing System Driving Cell and Gene therapies
14:00 (30 mins)
Michael Anbar, Horizon Discovery, a PerkinElmer company

Assist Plus Pipetting Platform
14:30 (5 mins)
Sharon Barnard — INTEGRA Biosciences

Bioluminescent assay tools for TCR-T and CAR-T development and characterisation
14:35 (5 mins)
Craig Malcolm — Promega UK Ltd

Armouring CAR-T cells therapy against the immunosuppressive microenvironment in solid tumour
14:40 (30 mins)
Romain Lara, AstraZeneca

Drug Discovery and Development in COPD

Preclinical translational models for investigating drugs for the treatment of COPD
14:00 (30 mins)
Simon Pitchford, King's College London

Use of human tissues to investigate drugs for the treatment of COPD
14:30 (30 mins)
Luigino Calzetta, University of Parma

2:00:

2:05:

2:10:

2:15:

2:20:

2:25:

2:30:

2:35:

2:40:

2:45:

2:50:

2:55:

3:00

3:00:

3:05:

3:10:

Refreshment Break

3:10:

3:15:

DDW - Accelerating Drug Discovery: Getting to the right molecule smarter & faster with automation- Sponsored by Bio Rad

Chairs: Zoe Hughes-Thomas, GSK

Singular Talent - Growing your company through great story telling

Chairs: Tom Froggatt, Singular Talent

3:15:

3:20:

3:25:

3:30:

3:35:

3:40:

3:45:

High Content Imaging in Drug Discovery

Morphological trajectory inference: Tracking cell state transitions and the impact of small-molecule perturbations
15:45 (30 mins)
Rebecca Hughes, University of Edinburgh

Magnetic Electrospun Microfibre Scaffold Assemblies: Examples of there use for Cell-Based Screening Applications
16:15 (15 mins)
Gary Allenby — Charnwood Molecular

Quantitative high-throughput screening of single cancer cell phenotypes in 3D matrices
16:30 (30 mins)
Vicky Bousgouni, Institute of Cancer Research

Overcoming Challenges and New Directions in Medicinal Chemistry

Targeting the template: A novel therapeutic strategy for prion diseases
15:45 (30 mins)
Heulyn Jones, Cardiff University

Navigate Your Chemistry And Explore The Biology - Case Studies Of CETSA® overcoming challenges in Drug Discovery
16:15 (15 mins)
Isabel Martin Caballero — Pelago Bioscience AB

Audience Lead Panel Discussion with Q&A
16:30 (30 mins)
Allan Jordan, Sygnature Discovery Sarah Skerrat, CHARM Therapeutics

Cell & Gene Therapy Sponsored by Miltenyi

Unlocking a revolutionary class of in vivo reprogramming therapies through systematic, unbiased identification of the key cell switches controlling cell fate
15:45 (30 mins)
Louise Modis, Mogrify

The impact of not understanding the genetic landscape, Ignorance will cost you time and money.
16:15 (15 mins)
Melanie Maerken — Synthego

Next Generation Platforms for Human Gene Therapy
16:30 (30 mins)
Aravind Asokan, Duke University

Drug Discovery and Development in COPD

Early experimental medicine studies for investigating new drugs for COPD
15:45 (30 mins)
Dave Singh, University of Manchester

Methods to tackle novel molecular targets involved in inflammatory disease
16:15 (15 mins)
Mark Abbott — Peak Proteins Ltd

Publishing in the British Journal of Pharmacology
16:30 (30 mins)
Charles Whalley, British Pharmacological Society

3:45:

3:50:

3:55:

4:00

4:00:

4:05:

4:10:

4:15:

4:20:

4:25:

4:30:

4:35:

4:40:

4:45:

4:50:

4:55:

5:00

Networking Event - Poster Session 18.30 - 19.00

5:00:

5:05:

5:10:

5:15:

Early Career Professionals: Careers in drug discovery - Network like a Boss

5:15:

5:20:

5:25:

5:30:

5:35:

5:40:

5:45:

5:50:

5:55:

6:00

6:00:

6:05:

6:10:

6:15:

6:20:

6:25:

6:30:

6:35:

6:40:

6:45:

6:50:

6:55:

7:00

ELRIG’s Celebration of Drug Discovery, sponsored by Synthego, at The Fox, ExCel

7:00: