Discovery Technologies 2021
Tuesday, 9 November 2021 to Wednesday, 10 November 2021
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Presentation
Tue 9 November
10 November
[Schedule with Sessions only]
DAY 1AuditoriumHelix Room
DAY 2
DAY 1AuditoriumHelix Room
DAY 2
8:00 8:00:
8:05: 8:05:
8:10: 8:10:
8:15: 8:15:
8:20: 8:20:
8:25: 8:25:
8:30: Event Registration 8:30:
8:35: 8:35:
8:40: 8:40:
8:45: 8:45:
8:50: 8:50:
8:55: 8:55:
9:00 9:00:
9:05: 9:05:
9:10: 9:10:
9:15:
Alderley Park Site Welcome
Chairs: Kath Mackay  
 9:15:
9:20:
Conference Welcome and Plenary Keynote Introduction
Chairs: Jarrod Walsh, AstraZeneca  
 9:20:
9:25:
Keynote Presentation
YouTube
Advances in Phenomics Drug Discovery: Combining high content and pathway profiling technologies with multiparametric data analysis tools to discover novel and effective drug mechanisms-of-action.
09:25 (50 mins)
Neil Carragher, University of Edinburgh  
YouTube
Bioluminescent Tools & Approaches for RAS Pathway Drug Discovery
10:15 (15 mins)
Craig Malcolm — Promega UK Ltd    
 9:25:
9:30: 9:30:
9:35: 9:35:
9:40: 9:40:
9:45: 9:45:
9:50: 9:50:
9:55: 9:55:
10:00 10:00
10:05 10:05
10:10 10:10
10:15 10:15
10:20 10:20
10:25 10:25
10:30 Refreshment Break 10:30
10:35 10:35
10:40 10:40
10:45 10:45
10:50 10:50
10:55 10:55
11:00 11:00
11:05 11:05
11:10 11:10
11:15
Emerging Discovery Strategies
Chairs: Emily Offer, Medicines Discovery Catapult  Graeme Walker, Sygnature Discovery  
YouTube
An update on the JUMP-CP Consortium: insights from pilot experiments and outlook
11:15 (30 mins)
Paula A. Marin-Zapata, Bayer  
R&D at the New Speed of Science - Accelerate your R&D Transformation with Benchling
11:45 (5 mins)
Jonathan Stone — Benchling    
YouTube
From Theraphosid to Therapy: Screening a venom library using high-throughput automated patch clamp to identify novel and selective sodium channel modulators
11:50 (30 mins)
Elaine Duncan, Charles River  Steven Trim, Venomtech Ltd  
Hit Triage
Chairs: Gareth Davies, AstraZeneca  Kirsty Winn, Medicines Discovery Catapult  
YouTube
Application of Acoustic Mist Ionisation MS to rapidly identify hits with undesirable mechanisms of action in HTS outputs
11:15 (30 mins)
Rachel Moore, AstraZeneca  
YouTube
Assist Plus
11:45 (5 mins)
Sharon Barnard — INTEGRA Biosciences    
YouTube
Case studies in cellular nuisance compounds
11:50 (30 mins)
Jayme Dahlin, National Center for Advancing Translational Science (NCATS)  
 11:15
11:20 11:20
11:25 11:25
11:30 11:30
11:35 11:35
11:40 11:40
11:45 11:45
11:50 11:50
11:55 11:55
12:00 12:00
12:05 12:05
12:10 12:10
12:15 12:15
12:20 12:20
12:25 Refreshment Break 12:25
12:30 12:30
12:35 12:35
12:40 12:40
12:45 12:45
12:50 12:50
12:55 12:55
1:00 1:00:
1:05: 1:05:
1:10: 1:10:
1:15: 1:15:
1:20: 1:20:
1:25: 1:25:
1:30: 1:30:
1:35: 1:35:
1:40: 1:40:
1:45: 1:45:
1:50: 1:50:
1:55: 1:55:
2:00
Emerging Discovery Strategies
Chairs: Emily Offer, Medicines Discovery Catapult  Graeme Walker, Sygnature Discovery  
YouTube
Fragment-based screening coupled to chemical proteomics as an emerging paradigm for early drug discovery in ER+ breast cancer
14:00 (30 mins)
Stephanie Constantinou, AstraZeneca  Aarti Kawatkar, AstraZeneca  
YouTube
CDD Vault - Complexity Simplified
14:30 (5 mins)
Tamsin Lamont — Collaborative Drug Discovery    
YouTube
The concept of G-quadruplex ligands as novel gene regulators and potential anticancer drugs
14:35 (30 mins)
Stephen Neidle, UCL School of Pharmacy  
Hit Triage
Chairs: Gareth Davies, AstraZeneca  Kirsty Winn, Medicines Discovery Catapult  
YouTube
Developing assay development tools to make screening less PAINS-full
14:00 (30 mins)
Stuart McElroy, BioAscent Discovery ltd.  
YouTube
An Introduction of the Medicines Discovery Catapult
14:30 (5 mins)
Martin Main — Medicines Discovery Catapult    
Computational and Empirical Strategies to Triage Nuisance Compounds in HTS
14:35 (30 mins)
Sarah Martin, Charles River  Scott Maidment, Charles River  
 2:00:
2:05: 2:05:
2:10: 2:10:
2:15: 2:15:
2:20: 2:20:
2:25: 2:25:
2:30: 2:30:
2:35: 2:35:
2:40: 2:40:
2:45: 2:45:
2:50: 2:50:
2:55: 2:55:
3:00 3:00:
3:05: Refreshment Break 3:05:
3:10: 3:10:
3:15: 3:15:
3:20: 3:20:
3:25: 3:25:
3:30: 3:30:
3:35:
Emerging Discovery Strategies
Chairs: Emily Offer, Medicines Discovery Catapult  Graeme Walker, Sygnature Discovery  
Right assay, right hit, right time. Identify “more physiological hits” earlier in drug discovery
15:35 (30 mins)
Kathy Dodgson, Aurelia Bioscience Ltd  
YouTube
Patient-derived cell models as a clinically-relevant drug discovery strategy
16:05 (30 mins)
Gareth Griffiths, Imagen Therapeutics  
Hit Triage
Chairs: Gareth Davies, AstraZeneca  Kirsty Winn, Medicines Discovery Catapult  
YouTube
Hit or Miss? The Importance of Triage in the Active to Hit Transition
15:35 (30 mins)
Alexandra Stowell, Sygnature Discovery  
YouTube
Pragmatic screening collection refinement to facilitate hit progression
16:05 (30 mins)
Kristian Birchall, LifeArc  
 3:35:
3:40: 3:40:
3:45: 3:45:
3:50: 3:50:
3:55: 3:55:
4:00 4:00:
4:05: 4:05:
4:10: 4:10:
4:15: 4:15:
4:20: 4:20:
4:25: 4:25:
4:30: 4:30:
4:35:
Networking Event
 4:35:
4:40: 4:40:
4:45: 4:45:
4:50: 4:50:
4:55: 4:55:
5:00 5:00:
5:05: 5:05:
5:10: 5:10:
5:15: 5:15:
5:20: 5:20:
5:25: 5:25:
5:30: 5:30:
5:35: 5:35:
5:40: 5:40:
5:45: 5:45:
5:50: 5:50:
5:55: 5:55:
6:00 6:00:
6:05: 6:05:
6:10: 6:10:
6:15: 6:15:
6:20: 6:20:
6:25: 6:25:
6:30: 6:30:
6:35: 6:35:
6:40: 6:40:
6:45: 6:45:
6:50: 6:50:
6:55: 6:55:
7:00 7:00: