CRISPR in Drug Discovery 2021
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Presentation
Tue 23 March
24 March
DAY 1Conference Hall
DAY 2
DAY 1Conference Hall
DAY 2
11:00
Welcome & Introductions
Welcome & Introductions
11:00 (5 mins)
Andrew Bassett, Wellcome Sanger Institute  Klio Maratou, GlaxoSmithKline  Marcello Maresca, AstraZeneca  
 11:00
11:05
Functional Genomics
Chairs: Andrew Bassett, Wellcome Sanger Institute  
YouTube
Functional Genomics to Guide Cancer Drug Discovery
11:05 (45 mins)
Mathew Garnett, Wellcome Sanger Institute  
YouTube
CRISPR screening to identify new drug targets in complex cell models
11:50 (30 mins)
Carlos le Sage — Horizon Discovery    
 11:05
11:10 11:10
11:15 11:15
11:20 11:20
11:25 11:25
11:30 11:30
11:35 11:35
11:40 11:40
11:45 11:45
11:50 11:50
11:55 11:55
12:00 12:00
12:05 12:05
12:10 12:10
12:15 12:15
12:20 Refreshment Break/Poster Session/Vendor Exhibition 12:20
12:25 12:25
12:30 12:30
12:35 12:35
12:40 12:40
12:45 12:45
12:50 12:50
12:55 12:55
1:00 1:00:
1:05: 1:05:
1:10: 1:10:
1:15: 1:15:
1:20:
Functional Genomics
Chairs: Andrew Bassett, Wellcome Sanger Institute  
Session Chair Welcome
13:20 (5 mins)
Andrew Bassett, Wellcome Sanger Institute  
Using CRISPR/Cas9 screens to study epidermal keratinocyte differentiation and inflammation
13:25 (20 mins)
Christopher Bryant, Wellcome Sanger Institute  
YouTube
Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles
13:45 (20 mins)
Ulrich Elling, Institute of Molecular Biotechnology, IMBA, Vienna  
Joint Q&A Session
14:05 (20 mins)
Mathew Garnett, Wellcome Sanger Institute  Christopher Bryant, Wellcome Sanger Institute  Ulrich Elling, Institute of Molecular Biotechnology, IMBA, Vienna  
YouTube
FirePlex Multiplexed Assay Technology – a Cell-line Profiling Tool
14:25 (15 mins)
Zeev Gechtman — Abcam    
 1:20:
1:25: 1:25:
1:30: 1:30:
1:35: 1:35:
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2:35: 2:35:
2:40: Refreshment Break 2:40:
2:45: 2:45:
2:50: 2:50:
2:55: 2:55:
3:00
Functional Genomics
Chairs: Marcello Maresca, AstraZeneca  
YouTube
Screening for functional transcriptional and splicing regulatory variants with GenIE
15:00 (20 mins)
Sarah Cooper , Wellcome Sanger Institute  
YouTube
CRISPR/Cas9 - from functional genomics applications to therapeutic genome editing
15:20 (20 mins)
Lars Steinmetz, EMBL   
YouTube
CRISPR Tools to Mitigate Attrition Rate Risk in Drug Development
15:40 (15 mins)
Kai Wilkens — Synthego     
YouTube
Accelerate functional genomics studies with simultaneous capture of CRISPR guides and gene expression profiles at single cell resolution.
15:55 (5 mins)
Stephen Hague — 10x Genomics    
 3:00:
3:05: 3:05:
3:10: 3:10:
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3:20: 3:20:
3:25: 3:25:
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3:45: 3:45:
3:50: 3:50:
3:55: 3:55:
4:00 Refreshment Break 4:00:
4:05: 4:05:
4:10: 4:10:
4:15:
Functional Genomics
Chairs: Marcello Maresca, AstraZeneca  
YouTube
Ultra-high throughput single-cell RNA sequencing and perturbation screening by combinatorial fluidic indexing
16:15 (20 mins)
Paul Datlinger, CeMM Research Center for Molecular Medicine, Vienna  
YouTube
A single-cell CRISPR screen in >100k primary human T cells
16:35 (5 mins)
Tilmann Buerckstuemmer — Aelian Biotechnology    
YouTube
Advanced iPSC technologies for neurodegenerative disease research
16:40 (20 mins)
Michael Ward, NIH/NINDS  
Joint Q&A Session
17:00 (20 mins)
Sarah Cooper , Wellcome Sanger Institute  Lars Steinmetz, EMBL   Paul Datlinger, CeMM Research Center for Molecular Medicine, Vienna  Michael Ward, NIH/NINDS  
 4:15:
4:20: 4:20:
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5:00 5:00:
5:05: 5:05:
5:10: 5:10:
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5:20:
YouTube
 Horizon Discovery
Hot Topic Discussion - Understanding the paradigm of cellular visualization
 5:20:
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