10th Anniversary Drug Discovery 2016

Discussion

Thu 13 October

14 October

DAY 1

ROOM 3

HALL 1C

HALL 1B

Room 11A

Room 11C

DAY 2

DAY 1

ROOM 3

HALL 1C

HALL 1B

Room 11A

Room 11C

DAY 2

8:00

Arrival, Registration & Coffee

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How can we build a new drug discovery ecosystem, which will complement Boston?
08:45 (45 mins)
Chas Bountra, Oxford SGC - University of Oxford

Please go to Plenary Keynote Room 3 Prof Chas Bountra, Oxford SGC - University of Oxford

Genedata AG
Genedata Workshop: Modern Screening Data Analysis:Mastering Biological, Technical and Collaborative Complexity

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Chair Intro: Innovations in Chemistry Session
Chairs: Simon Ward, University of Sussex Ed Tate, Imperial College London

Chair Intro: Translational & Predictive Models Session
Chairs: Malcolm Haddrick, AstraZeneca Veronique Birault, Crick Institute

Oncology & Immunology Session
Chairs: Namir Hassan, Immunocore David Gilham, Manchester Cancer Research Centre

Welcome and Introduction. Speaker - Stephan Heyse, Genedata

Labcyte Inc.
Labcyte Workshop - Introduction to TRACK 1

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A foundation in the murky waters of Discovery: Layering a platform across piles of in-vitro screens. Speaker - Margarita Shatalina, Genedata

9:40:

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Sugars and Proteins
09:45 (45 mins)
Keynote Speaker: Ben Davis, Oxford University

Small Cell Lung Cancer Circulating Tumour Cell-Derived Explants - A New Preclinical Platform for Examining Drug Response
09:45 (45 mins)
Keynote Speaker: Kris Frese , Manchester University

Immuno-oncology:harnessing the immune system to combat cancer
09:45 (45 mins)
Keynote Speaker: Robert Wilkinson, Medimmune

Automated Acoustic Dispensing:Clinic and Research. Speaker - Kristin Blom, University Hospital Uppsala, Sweden

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10:00

Integrating screening data across a large multisite pharma organization. Speaker - Dave Murray, AstraZeneca

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Targeting Individual Cancers Using Chemical Systems Medicine. Speaker - Krister Wennerberg, Institute of Molecular Medicine, Finland

10:20

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Specific Correction of Alternative Survival Motor Neuron 2 (SMN2) Splicing by Small Molecules: Discovery of a Potential Novel Medicine to Treat Spinal Muscular Atrophy
10:30 (30 mins)
Hasane Ratni, Roche

Chip-Based Microphysiological Systems and Drug Discovery
10:30 (30 mins)
Uwe Marxx, TissUse

Biomarker Strategy to Guide Clinical Development of ImmTACTM molecules, a Novel Class of Biologic Drugs Based on Proprietary T cell receptor (TCR) Technology
10:30 (30 mins)
David Krige, ImmunoCore

Phenotypic high-content screen measuring aggregate clearance in neurodegenerative diseases. Speaker - Emilie Bureau, MRCT

10:30

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11:00

Coffee Break in The Exhibition Hall

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Chemical Tools to Manipulate Bacterial Virulence
11:30 (30 mins)
Stephan Seiber, TU Munich

Confocal High Content Screening of Cardiac and Liver Microtissues for the Improved Prediction of Drug Induced Toxicity
11:30 (30 mins)
Paul Walker, Cyprotex

TBC
11:30 (30 mins)
Martin Pule, UCL

High-content screening:How to easily select meaningful feature combinations. Speaker - Lope Florez, Genedata

Labcyte Workshop - Introduction to TRACK 2

11:30

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From Routine to Extreme Cherry Picking. Design of New Acoustically Compatible Storage Tubes for Liquid Samples. Speaker - Clive Green, AstraZeneca

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12:00

Poster Tasters
Chloe Koulouris - University of Sussex - Characterisation of serine racemase as a novel approach to modulating NMDA receptor function Gina Washbourn - University of Liverpool - The Synthesis and Biological Evaluation of Carbamoyl Triazoles as Potential Antituberculosis Protease Inhibitors

Poster Tasters
Eve Rogers - University of Liverpool - Exploring the Potential of the Physico-Mechanical Environment and Circadian Timing in Adult Stem Cell Differentiation. Matthew Burnham - AstraZeneca - Characterisation of stem cell derived cardiomyocyte spheroids using the CardioExcyte platform.

Poster Tasters
Arune Balaikaite - MRC Technology - T-cell epitopes, virus-like particles and extracellular loop fusions for challenging antibody generation. Aisha Alsfouk - Strathclyde University - Development of selective IKKα inhibitors as a treatment for prostate cancer therapy

Drug combinations as potential oncology therapeutics:Data analysis with Genedata Screener. Speaker - Michelle Newman, MRCT

12:00

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Echo-MS A Versatile Platform for Ultrafast Mass Spectrometry Analysis in Drug Discovery. Speaker - Ian Sinclair, AstraZeneca

12:15

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Snapshots (max 5 companies)

Takara Bio Europe
Professor Geny Groothius presents: Precision-cut tissue slices as translational and predictive ex vivo model for ADME and toxicity. Sponsored by Takara Bio

Snapshots (max 5 companies)

Simplifying synergy: Combination screens. Speaker - John Vincent, AstraZeneca

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1:00

Lunch in The Exhibition Hall (Exhibition, Posters, Lunchtime Workshops?)

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Drug Safety in Drug Development
14:30 (45 mins)
Keynote Speaker: Munir Pirmohamed , Drug Safety in Drug Development - THURS

Please go to Keynote Room 3 Munir Pirmohamed , Drug Safety in Drug Development

2:30:

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Beyond Small Molecule Inhibition: New Possibilities Through Induced Intracellular Protein Degradation
15:15 (30 mins)
John Harling, GSK

Application of an In vitro Human Airway Epithelial 3D Model for the Detection of Lung Irritancy Following Drug Treatment
15:15 (30 mins)
Ellinor Hornberg, AstraZeneca

Circulating tumour cells as a versatile liquid biopsy to manage cancer patient treatment and explore the biology of metastases
15:15 (30 mins)
Caroline Dive, Manchester University

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Small-Molecule Stabilization of 14-3-3 PPls: Possible New Approaches in Cancer, Cystic Fibrosis and Parkinson's Disease.
15:45 (30 mins)
Christian Ottman, Eindhoven

High-Efficiency Cellular Reprogramming with Microfluidics for Patient-Specific Disease Modelling
15:45 (30 mins)
Nicola Elvassore, UCL

Analysis of Reciprocal Tumour-Stroma Signalling by Cell-Specific Phosphoproteomics
15:45 (30 mins)
Claus Jorgensen, Cancer Research UK Manchester Institute

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From Fragment Hits to Selective Nanomolar Inhibitors of Human PAICS Without X-ray
16:15 (30 mins)
Andy Merritt, MRC Technology

Intestinal organoids: disease modelling and regenerative medicine
16:15 (30 mins)
Vivian Li, The Francis Crick Institute

Immunotherapy in the 21st Century: A Game Changing Paradigm in Oncology
16:15 (30 mins)
Thierry Wurch, Servier

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16:45-17:45 Poster Session 17.00 - 17.30 Dragons Den 17:00-19:00 Networking/Drinks Reception

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GALA CELEBRATION at The Museum of Liverpool 18.30 - Welcome Drinks & Canapes 21.00 - Close

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