BSP Spring Meeting 2016, London - From Science to Solutions: optimising control of parasitic diseases

Talk

11 April

12 April

Wed 13 April

[Schedule with Sessions only]

DAY 2

Lt 308 - Huxley Building

Great Hall - Sherfield Building

Lt 311 - Huxley Building

Lt 340 - Huxley Building

Poster / Exhibition hall - Sherfield Building

DAY 3

DAY 2

Lt 308 - Huxley Building

Great Hall - Sherfield Building

Lt 311 - Huxley Building

Lt 340 - Huxley Building

Poster / Exhibition hall - Sherfield Building

DAY 3

8:00

Registration in Main foyer of Sherfield Building

8:00:

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9:00

BES: 5 - Co-infections

Chairs: Ruth Kirk, School of Life Sciences

Coinfections and heterologous reactivity: a case study of Theileria
09:00 (30 mins)
Keynote Speaker: Mark Woolhouse, Univeristy of Edinburgh

Dientamoebiasis: an emerging human diarrhoeal disease and its diagnosis
09:30 (15 mins)
John Ellis, University of Technology Sydney

Assessing the impact of mass deworming on worm burden and co-infections with other parasites and commensals using molecular techniques
09:45 (15 mins)
Alice Easton, National Institutes of Health, USA

Helminths coinfection patterns in a population of Rattus norvegicus from an urban Brazilian slum affected by human leptospirosis
10:00 (15 mins)
Ticiana Carvalho Pereira, University of Liverpool

Nematode diversity in feral Soay sheep
10:15 (15 mins)
Alexandra Chambers, The Roslin Institute (The University of Edinburgh)

NTDs: 5 - Functional Genomics

Chairs: Russell Stothard, Liverpool School of Tropical Medicine

Developing & applying ‘poly-omics’ tools to enrich our understanding of schistosome biology
09:00 (30 mins)
Keynote Speaker: Karl Hoffman, University of Aberystwyth

Functional genomics for schistosomes: retroviral-based transgenesis and CRISPR-Cas9
09:30 (15 mins)
Gabriel Rinaldi, Wellcome Trust Sanger Institute

The genome of Onchocerca volvulus: a first view of filarial chromosomes
09:45 (15 mins)
James Cotton, Wellcome Trust Sanger Institute

Protein families with a putative role in parasitism in Strongyloides nematodes
10:00 (15 mins)
Vicky Hunt, University of Liverpool

Museomics; an emerging tool for disease research in parasitology
10:15 (15 mins)
Andrew Briscoe, NHM

Apicomplexa: 4 - Chemotherapy and Control I

Chairs: Andrew Blaborough, Imperial College London

Chemotherapy to fight malaria, selected travel notes and snapshots of an ongoing journey
09:00 (30 mins)
Keynote Speaker: Ilaria Russo, Univeristy of Manchester

Screening the MMV “Malaria Box” for rapid rate-of-kill
09:30 (15 mins)
Imran Ullah, Keele University

Vaccination against Eimeria ameliorates drug resistance in commercial poultry production.
09:45 (15 mins)
David Chapman, University of Arkansas

Role of an S-S link between cysteines 532 and 580 of the P. falciparum K13 Kelch propeller
10:00 (30 mins)
David Warhurst, LSHTM

Trypanosomiasis and Leishmaniasis: 4 - Diagnostics

Chairs: Michael Barrett, University of Glasgow

Elimination of sleeping sickness requires implementation of novel tools and strategies
09:00 (30 mins)
Keynote Speaker: Joseph Ndung'u, FIND, Gene

Expression of Trypanosoma brucei gambiense antigens in Leishmania tarentolae. Potential for use in rapid serodiagnostic tests (RDTs)
09:30 (15 mins)
Barrie Rooney, University of Kent

Metabolic markers of human African trypanosomiasis (HAT)
09:45 (15 mins)
Isabel Vincent, University of Glasgow

Quantifying the progression of visceral leishmaniasis
10:00 (15 mins)
Lloyd Chapman, University of Warwick

Exploring anti-α-gal antibodies as a novel tool for diagnosing infections of old world cutaneous leishmaniasis
10:15 (15 mins)
Krishanthi Subramaniam, Liverpool School of Tropical Medicine

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Tea and Coffee in main exhibition hall

Tea and Coffee

10:30

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11:00

BES: 6 - General Parasite Ecology

Chairs: Jo Cable, University of Cardiff

Reconstructing transmission processes from different data types
11:00 (30 mins)
Keynote Speaker: Dan Haydon, Univeristy of Glasgow

Juvenile immunity, growth, parasite load and fitness in wild Soay sheep
11:30 (15 mins)
Rebecca Watson, University of Edinburgh

People, parasites and wildlife – a balanced one-health perspective, not a one-way street
11:45 (15 mins)
RC Andrew Thompson, Murdoch University

Maternal transfer of helminth-specific antibodies and fitness in neonatal Soay sheep
12:00 (15 mins)
Alexandra Sparks, University of Edinburgh

NTDs: 6 - In Vitro and In Vivo Molecular Insights

Chairs: Karl Hoffman, University of Aberystwyth

Schistosoma life in the blood (and in the lab) illuminated by RNA-sequencing
11:00 (15 mins)
Arporn Wangwiwatsin, Wellcome Trust Sanger Institute

A mouse model for the dynamic imaging of collagen deposition during hepatic schistosomiasis
11:15 (15 mins)
Geoffrey Gobert, Queen's University Belfast

New macrofilaricide discovery and development through targeting Wolbachia
11:30 (15 mins)
Kelly Johnston, Liverpool School of Tropical Medicine

Re-purposing the Medicines for Malaria Venture compound library against the Wolbachia endosymbiont drug target for lymphatic filariasis and onchocerciasis
11:45 (15 mins)
Rachel Clare, Liverpool School of Tropical Medicine

Development of murine models of loiasis to assess microfilaricidal activity of pre-clinical candidate anti-filarial drugs
12:00 (15 mins)
Hanna Sjoberg, Liverpool School of Tropical Medicine

Apicomplexa: 5 - Chemotherapy and Control II

Chairs: Ilaria Russo, Univeristy of Manchester

Pfk13-independent resistance mechanisms in Plasmodium falciparum: a potential threat to ACT efficacy in Africa
11:00 (30 mins)
Colin Sutherland, London School of Hygiene & Tropical Medicine

Normocyte binding protein NBPXa is required for human erythrocyte invasion by Plasmodium knowlesi
11:30 (15 mins)
Robert Moon, London School of Hygiene and Tropical Medicine

Attraction of malaria mosquitoes to children infected with (different life cycle stages of) Plasmodium falciparum.
11:45 (15 mins)
Annette Busula, Wageningen University and Research Centre

The in vitro pharmacodynamic response of antimalarial endoperoxides on P. falciparum gametocytes
12:00 (15 mins)
Ahmed Saif, Liverpool School of Tropical Medicine

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12:15

Lunch

12:15

12:20

12:25

BSP AGM
12:25 (20 mins)

12:25

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12:45

Optional Wormbase workshop (room CLORE 270)
12:45 (75 mins)
parasite.wormbase.org is a web-based resource for storing, analyzing and exploring the genomes of helminth parasites. The database contains annotated genomes for 90 species of nematode and platyhelminth. In this workshop, we will provide an introduction to WormBase ParaSite, and walk through its major features and tools. You will need to bring a laptop with a standard browser, connected to the wireless internet. To attend the workshop, please fill in this short form: parasite.wormbase.org/works

Modelling Workshop
12:45 (75 mins)
Free Modelling Workshop. An introductory talk by Drs Deidre Hollingsworth and Kat Rock on what models can do for you. Then speed presentations (1-3 slides) from modellers and early career researchers, who might want to work with modellers. This will be followed by an interactive session to help introduce and bring together epidemiologists and modellers. Please email your interest in presenting a speed talk to Alison (a.bettis@imperial.ac.uk), or sign up to just attend and or simply just find out

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2:00

BES: 7 - Aquatic Parasitology and Perturbations

Chairs: Scott Paul Lawton, Kingston University

Aquatic parasitology in a changing world: diversity, emerging diseases and climate change
14:00 (30 mins)
Keynote Speaker: Nico Smit, North-West University

Aquatic Parasite Information - a new resource for data on freshwater fish parasites in the UK
14:30 (15 mins)
Bernice Brewster, Kingston University

Fish in an ever uncertain climate: a tale of two parasites
14:45 (15 mins)
Alexander Stewart, Cardiff University

Effects of flow rate on parasite transmission and fish shoaling behaviour
15:00 (15 mins)
Michael Reynolds, Cardiff University

NTDs: 7 - Controll, elimination and diagnostics I

Chairs: David Rollinson, Natural History Museum

The era of elimination: progress and challenges in fighting helminthiases
14:00 (30 mins)
Keynote Speaker: Steffi Knopp, Swiss Tropical and Public Health Institute and Natural History Museum, London

Quantifying polyparasitism in Beira, Mozambique: Detection of intestinal parasites in fecal samples by microscopy and real-time PCR
14:30 (15 mins)
Lynn Meurs, Institute of Tropical Medicine

Diagnosis of active Schistosoma infection in a non-endemic clinical setting using the ultrasensitive lateral flow test for detection of schistosome Circulating Anodic Antigen (CAA) in serum.
14:45 (15 mins)
Lisette van Lieshout, Leiden University Medical Center

Efficacy of triple drug regimen in the global elimination of Lymphatic Filariasis
15:00 (15 mins)
Michael Irvine, University of Warwick

Apicomplexa: 6 - Cell biology

Chairs: Paul Horrocks, Keele University

Molecular switches controlling atypical mitosis in Plasmodium
14:00 (30 mins)
Keynote Speaker: Rita Tewari, University of Nottingham

Biogenesis of the crystalloid organelle in Plasmodium involves microtubule-dependent vesicle transport and assembly.
14:30 (15 mins)
sadia saeed, London school of hygiene and tropical medicine

Signalling networks during Toxoplasma invasion: calcium provides both positive and negative control of organelle secretion.
14:45 (15 mins)
Ross Waller, University of Cambridge

The role of DC8 and 13 PfEMP1 domains in cytoadhesion of Plasmodium falciparum to human brain endothelial cells
15:00 (15 mins)
Yvonne Azasi, University of Edinburgh

Helminth Signalling and Developmental Parasitology I

Chairs: Johnathan Dazell, Queen's University Belfast

Reprogramming global animal state in C. elegans by O2 and CO2 sensing circuits
14:00 (30 mins)
Keynote Speaker: Mario de Bono , MRC - Laboratory of Molecular Biology

Probing the role of miRNAs in the growth and development of the liver fluke, Fasciola hepatica
14:30 (15 mins)
Claire Hill, Queen's University Belfast

From planarians to parasitism: Wnt/Hedgehog signalling controls AP patterning during larval and strobilar development in tapeworms
14:45 (15 mins)
Francesca Jarero, Natural History Museum

Unexpected activity of a novel kunitz-type parasite inhibitor: inhibition of cathepsins and not serine proteases
15:00 (15 mins)
David Smith, Queen's University Belfast

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Tea and Coffee in main exhibition hall

Tea and Coffee

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BES: 8 - General Wildlife and Plant Parasitology

Chairs: Nico Smit, North-West University

Molecular Characterization of Leptospira Species Isolated from Urban Rats in Peninsular Malaysia
15:45 (15 mins)
Siti Nursheena Mohd Zain, University of Malaya

From mummy, with love - on vertical transmission of Babesia microti in Microtus spp.
16:00 (15 mins)
Katarzyna Tołkacz, Department of Parasitology, Faculty of Biology

Developing Neuropeptides as Transgenic Nematicides
16:15 (15 mins)
Leonie Wilson, Queen's University Belfast

ExoRNAi exposes contrasting roles for sugar exudation in host-finding by plant pathogens
16:30 (15 mins)
Neil Warnock, Queens University Belfast

NTDs: 8 - Control, elimination and diagnostics II

Chairs: Steffi Knopp, Swiss Tropical and Public Health Institute and Natural History Museum, London

Diagnostics of schistosomiasis by antigen-detection (CAA and CCA): the quest for a single worm.
15:45 (15 mins)
Govert van Dam, LUMC -Dept. of Parasitology

COUNTDOWN in Ghana: Developing the diagnostic capacity for detection and surveillance of soil-transmitted helminthiasis at local and national levels
16:00 (15 mins)
Lucas Cunningham, Liverpool School of Tropical Medicine

Community-wide patterns of infection following standard treatment for schistosomiasis and soil-transmitted helminths from a 2 year study in Uganda
16:15 (15 mins)
Arminder Deol, Schistosomiasis Control Initiative

A novel methodology to assess diagnostic performance when ambiguous results are present, with application to Schistosoma mansoni detection in Côte d’Ivoire and Uganda
16:30 (15 mins)
Michelle Clements, Schistosomiasis Control Initiative

Apicomplexa: 7 - Cell and Molecular Biology

Chairs: Rita Tewari, University of Nottingham

A comparative study of malaria parasite cell death following exposure to titratable lethal doses of antimalarial drugs
15:45 (15 mins)
Ibrahim Ali, Keele University

A new long-term cell culturing system for Cryptosporidium
16:00 (15 mins)
Anastasios Tsaousis, University of Kent

Plasmodium merozoite motility in red cell invasion: an ultrastructural model of how the actin-myosin motor directs propulsion.
16:15 (15 mins)
Lawrence Bannister, king's college london

Functional analyses of putative assortative-mating genes between the molecular forms of Anopheles gambiae
16:30 (15 mins)
Nancy Dawam, Keele University

Helminth Signalling and Developmental Parasitology II

Chairs: Mario de Bono , MRC - Laboratory of Molecular Biology

Tapeworm tumours: how not to make a helminth
15:45 (30 mins)
Peter Olson, The Natural History Museum

Akt signalling in the human parasite Schistosoma mansoni
16:15 (15 mins)
Maxine Mckenzie, Faculty of Life Sciences - Kingston University

Detecting Molecular Similarities Between Allergenic And Metazoan Parasitic Proteins: Allergy In The Light of Immunity
16:30 (15 mins)
Nicholas Furnham, London School of Hygiene and Tropical Medicine

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5:00

Plenary 6

Wright Medal Lecture - Decoding antitrypanosomal drug action and resistance
17:00 (30 mins)
Keynote Speaker: David Horn, University of Dundee

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Break

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7:00

BSP Gala Dinner
19:00 (180 mins)
In the senior common room on the first floor

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Last talk

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