BSP Spring Meeting 2018

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DAY 1

Great Hall, Arts Centre

Stream 1 - Edward Llwyd 0.26 Biology Main

Stream 2 - Llandinam A6

Stream 3 - Physics 0.15 Main

Stream 4 - Edward Llwyd 0.01

DAY 1

Stream 5 - IBERS 0.33 (Monday), Physisc 0.11 (Tuesday & Wednesday)

Students Union Building

DAY 3

8:00

Registration

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Welcome Address

Great Hall, Arts Centre

Welcome Address
08:45 (15 mins)
Justin Pachebat, IBERS, Aberystwyth University

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9:00

Plenary 0

Great Hall, Arts Centre

Welcome Address
09:00 (15 mins)
Karl Hoffmann, IBERS, Aberystwyth University

9:00

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9:15:

Plenary I

Chairs: Karl Hoffmann, IBERS, Aberystwyth University

Great Hall, Arts Centre

Hookworms and their secreted proteins as a novel anti-inflammatory modality
09:15 (45 mins)
Keynote Speaker: Alex Loukas, James Cook University

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10:00

Plenary II

Chairs: Karl Hoffmann, IBERS, Aberystwyth University

Great Hall, Arts Centre

The evolution of sociality and division of labour in trematode parasites
10:00 (45 mins)
Keynote Speaker: Robert Poulin, Otago University

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Coffee Break

10:45

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11:15

Tryps & Leish Therapeutics, diagnostics & epidemiology I - Sponsored by Elsevier

Chairs: Mark Field, University of Dundee

Stream 1 - Edward Llwyd 0.26 Biology Main

Drug target deconvolution in the kinetoplastids
11:15 (30 mins)
Keynote Speaker: Susan Wyllie — Elsevier

The structure of serum resistance-associated protein and its implications for human African trypanosomiasis
11:45 (15 mins)
Sebastian Zoll, University of Oxford

Mode of action of the anti-trypanosomal benzoxaborole AN7973
12:00 (15 mins)
Christine Clayton, ZMBH

Trypanosoma brucei 20S proteasome homology modeling and validation of compound interaction assist in designing novel proteasome inhibitors
12:15 (15 mins)
Srinivasa P S Rao, Novartis Institute for Tropical Diseases

Trypanosomes and their bloody matrix: microfluidic separation approaches
12:30 (15 mins)
Axel Hochstetter, University of Glasgow

Protozoa: Cell Biology & Immunology I - Sponsored by William Powell

Chairs: Tony Holder, The Francis Crick Institute

Stream 2 - Llandinam A6

Immune-mediated control of Toxoplasma in human cells
11:15 (30 mins)
Keynote Speaker: Eva Frickel, Francis Crick Institute

Functional characterization of mitochondrial translation components in the early diverging eukaryote Toxoplasma gondii.
11:45 (15 mins)
Alice Lacombe, University of Glasgow

Development of modified organoid culture protocols for interrogation of interactions between Toxoplasma gondii and the intestinal epithelium
12:00 (15 mins)
Janine Coombes, University of Liverpool

Serotyping and genotyping studies reveal indigenous atypical type II Toxoplasma strains are associated with symptomatic infection of patients in Australia
12:15 (15 mins)
John Ellis, University of Technology Sydney

Apicomplexan C-mannosyltransferases modify adhesins of the TRAP family
12:30 (15 mins)
Andreia Albuquerque-Wendt, Medical School of Hannover

Helminths: Drug Discovery & Resistance I Sponsor - Life Sciences Research Network Wales

Chairs: Jane Hodgkinson, UOL

Stream 3 - Physics 0.15 Main

Targeting epigenetic mechanisms for drug development against Neglected Parasitic Diseases: the A-ParaDDisE project and beyond
11:15 (30 mins)
Keynote Speaker: Raymond Pierce — Techion Group Ltd

Targeting the histone methylation machinery in Schistosoma mansoni
11:45 (15 mins)
Gilda Padalino, Aberystwyth University

Curcumin induced biochemical and tegumental surface changes in a digenetic fluke : Clinostomum complanatum.
12:00 (15 mins)
Lubna Rehman, Aligarh Muslim University

Computationally-Guided Drug Repurposing Enables the Discovery of Kinase Targets and Inhibitors as New Schistosomicidal Agents
12:15 (15 mins)
Nicholas Furnham, London School of Hygiene and Tropical Medicine

In silico profiling and prediction of putative neuropeptide ligand-receptor interactions in parasitic nematodes
12:30 (15 mins)
Fiona Mc Kay, Queen's University Belfast

Ecological Parasitology I

Chairs: Jo Cable, Cardiff University

Stream 4 - Edward Llwyd 0.01

Throwing the baby out with the bath water: impact of parasite control treatments on non-target organisms
11:15 (30 mins)
Keynote Speaker: Rachel Paterson, Cardiff University

Are parasites stressful?
11:45 (15 mins)
Katie O'Dwyer, Home

Effects of host’s altered food ration on host-parasite interaction in changing environment
12:00 (15 mins)
Saman Yaqub, University of Leicester, UK

Warming can alter host behaviour to the same extent as behaviour-manipulating parasites
12:15 (15 mins)
Maureen Williams, Trinity College Dublin

Human history, drugs and climate shape the global diversity of Haemonchus contortus populations
12:30 (15 mins)
Guillaume Sallé, INRA

11:15

In vitro Technologies in Cryptosporidium Research: Workshop 1

Chairs: Anna Paziewska-Harris, Cardiff University

Stream 5 - IBERS 0.33 (Monday), Physisc 0.11 (Tuesday & Wednesday)

Advances in In vitro culture of Cryptosporidium
11:15 (15 mins)
Keynote Speaker: Nigel Yarlett — NC3RS

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Lunch

12:45

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1:00

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2:00

Tryps & Leish Cell & Molecular Biology I

Chairs: Mark Field, University of Dundee

Stream 1 - Edward Llwyd 0.26 Biology Main

Co-transcriptional nuclear export of trypanosome mRNAs
14:00 (30 mins)
Keynote Speaker: Susanne Kramer, Biozentrum, Lehrstuhl für Zell-und Entwicklungsbiologie, Universität Würzburg

Towards a whole genome CRISPR-CAS9 loss of function screen to study the mode of action and resistance to drugs in Leishmania
14:30 (15 mins)
Ana Maria Mejia , Université Laval

Gluconeogenesis in bloodstream-form Trypanosoma brucei
14:45 (15 mins)
Julie Kovarova, University of Dundee

Global gene expression analysis during the Trypanosoma cruzi life cycle identifies regulatory RNA Binding Proteins involved with metacyclogenesis and parasite virulence
15:00 (15 mins)
Santuza Maria Teixeira, Federal University of Minas Gerais

Co-localisation of two simultaneously active VSG expression sites in ‘double-expresser’ T. brucei strains
15:15 (15 mins)
James Budzak, Imperial College London

Clinical Parasitology

Chairs: Peter Chiodini, UCL Hospital for Tropical Diseases Roger Evans, NHS

Stream 2 - Llandinam A6

Toxoplasma and transplants: forewarned is forearmed
14:00 (20 mins)
Keynote Speaker: Roger Evans, NHS

Life as a clinical parasitologist
14:20 (20 mins)
Keynote Speaker: Peter Chiodini, UCL Hospital for Tropical Diseases

Prevalence of malaria, urinary schistosomiasis, typhoid fever and hepatitis b virus co-infection among school children in Ogbese, Ise-Ekiti, South-Western, Nigeria.
14:40 (10 mins)
Charles Ayorinde, The Federal Polytechnic Adoekiti

Epidemiology of Trichomonas vaginalis infection among infertile women in Gaza city, Palestine
14:50 (10 mins)
Adnan Al-Hindi, Islamic University-Gaza, Faculty of Health Science

A rapid ATP bioluminescence assay for antimicrobial susceptibility testing of Acanthamoeba; cysts and trophozoites
15:00 (10 mins)
Tim Paget, University of Sunderland

Treatment of individuals living with neurocysticercosis and HIV/AIDS: a systematic review
15:10 (10 mins)
Maria-Gloria Basanez, Imperial College London, Faculty of Medicine

Designing antifilarial drug trials using clinical trial simulators: the case of river blindness
15:20 (10 mins)
Martin Walker, Royal Veterinary College

Helminths: Molecular Communication. Sponsor - Zoetis

Chairs: Russell Morphew, Institute of Biological, Environmental and Rural Sciences

Stream 3 - Physics 0.15 Main

Small RNAs in nematode-host interactions
14:00 (30 mins)
Keynote Speaker: Amy Buck, University of Edinburgh

Nematode microRNAs – roles in development and host-parasite interactions
14:30 (15 mins)
Collette Britton, University of Glasgow

Characterisation of Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) an immunogenic, schistosome-specific, protein exhibiting developmentally regulated alternative splicing
14:45 (15 mins)
Thomas Gasan, Aberystwyth Univerisy

Optimisation Of Parasitic Extracellular Vesicle Purification for Downstream Analysis To Understand Their Role Within Drug Exposure
15:00 (15 mins)
Chelsea Davis, Aberystwyth University

MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni
15:15 (15 mins)
Anna Protasio, NCBS-Instem-Cambridge Fellowship

Wormbase Parasite
15:30 (10 mins)
Keynote Speaker: Kevin Howe, EMBL-EBI

Ecological Parasitology: Eco-Immunology.

Chairs: Mark Viney, University of Liverpool Joe Jackson, University of Salford

Stream 4 - Edward Llwyd 0.01

Food and environmental temperature predominantly drive immune allocation and infection resistance in wild fish
14:00 (30 mins)
Keynote Speaker: Joe Jackson, University of Salford

The Immune State of Wild Mice, Mus musculus domesticus
14:30 (15 mins)
Mark Viney, University of Liverpool

Fungal communities in the Field Vole (Microtus agrestis) and their possible impact on host immunology and disease risk
14:45 (15 mins)
Anna Thomason, University of Salford

Assessing the Darwinian costs of mounting an adaptive immune response
15:00 (15 mins)
Dominik Schmid, Queen Mary University London

Taking a step into the unknowns of myoxozoan genomics: Sequencing and functional characterisation of a myxozoan micro-exon gene
15:15 (15 mins)
Jason Holland, University of Aberdeen

2:00

In vitro Technologies in Cryptosporidium Research Workshop 2

Chairs: Anna Paziewska-Harris, Cardiff University

Stream 5 - IBERS 0.33 (Monday), Physisc 0.11 (Tuesday & Wednesday)

Advances in In vitro culture of Cryptosporidium
14:00 (15 mins)
Keynote Speaker: Nigel Yarlett — NC3RS

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Coffee Break

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Tryps & Leish Therapeutics, diagnostics & epidemiology II- Sponsored by Elsvier

Chairs: Annette MacLeod, University of Glasgow

Stream 1 - Edward Llwyd 0.26 Biology Main

Towards the next generation of drugs for African trypanosomiasis
16:15 (30 mins)
Keynote Speaker: Pascal Mäser, Swiss Tropical and Public Health Institute

Rapid accumulation of suramin in bloodstream form trypanosomes leads to differentiation related metabolic switching
16:45 (15 mins)
Mark Field, University of Dundee

More than immune evasion – a variant surface glycoprotein causes in vitro suramin resistance in Trypanosoma brucei
17:00 (15 mins)
Natalie Wiedemar, Swiss Tropical and Public Health Institute

Minor groove binders as antitrypanosomal agents for animal African trypanosomiasis
17:15 (15 mins)
Federica Giordani, University of Glasgow

Dīvide et īmpera: Chromosome segregation in Trypanosoma brucei, a target deconvolution view.
17:30 (15 mins)
Manuel Saldivia, University of York

Protozoa: Drug Discovery & Resistance

Chairs: Paul Horrocks, Institute for Science and Technology in Medicine Colin Sutherland, London School of Hygiene & Tropical Medicine

Stream 2 - Llandinam A6

Antimalarial pharmacology of primaquine: Attempting to solve a 70 year-old puzzle
16:15 (30 mins)
Keynote Speaker: Giancarlo Biagini, Liverpool School of Tropical Medicine

RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics.
16:45 (15 mins)
Catherine Merrick, Keele University

Artemisinin resistance? Mind the traffic ...
17:00 (15 mins)
Colin Sutherland, London School of Hygiene & Tropical Medicine

Repositioning of synthetic emetine analogues as potential anti-malarial drugs and use of molecular modelling tools to aid in drug discovery
17:15 (15 mins)
Priyanka Panwar, University of Salford

Exploring the potential of autophagy as a novel drug target: SK1.49 as a chemical probe of autophagy in Plasmodium falciparum
17:30 (15 mins)
Paul Horrocks, Institute for Science and Technology in Medicine

Helminths: Intermediate host - parasite interactions. Sponsor - Zoetis

Chairs: Jim Collins, UT Southwestern Medical Cente

Stream 3 - Physics 0.15 Main

First contact - Release of schistosome exosome-like extracellular vesicles during early intramolluscan larval development
16:15 (30 mins)
Keynote Speaker: Tim Yoshino, University of Wisconsin-Madison

Comparing the population genetic structure of snail hosts and their schistosome parasites in Northern Senegal
16:45 (15 mins)
Tine Huyse, Royal Museum for Central Africa

Snail infection / pre-patent surveillance approach for intestinal schistosomiasis control and elimination programs: Tanzania
17:00 (15 mins)
Tom Pennance, Natural History Museum

Farewell to the God of Plague: Conquering schistosomiasis in China; the last mile
17:15 (15 mins)
Don McManus, QIMR Berghofer Medical Research Institute

Experimental evaluation of behavioural changes in gilt-head seabream infected with brain-encysted metacercariae of Cardiocephaloides longicollis (Trematoda, Strigeidae)
17:30 (15 mins)
Ana Born-Torrijos, Institute of Parasitology, Biology Centre, ASCR

Ecological Parasitology: Multi-species Interactions

Stream 4 - Edward Llwyd 0.01

Unravelling Interactions Between Schistosomes, the Microbiome and Anti-Helminthic Drugs in a Ugandan Field Setting.
16:15 (15 mins)
Lauren Carruthers, University of Glasgow

The effect of endemic macroparasite on the quality and quantity of an epidemic parasite
16:30 (15 mins)
Oluwaseun Somoye, Cardiff university

Strongyloides stercoralis infection in humans and its association with increased gut microbial diversity
16:45 (15 mins)
Timothy Jenkins, Mr

Social stress alters transcriptomic responses to infection and dysregulates molecular body clocks
17:00 (15 mins)
Amy Ellison, Cardiff University

Murine schistosomiasis quantitatively and qualitatively modifies the intestinal microbiota
17:15 (15 mins)
Laura Peachey, University of Cambridge

4:15:

Commercialising Research Workshop

Chairs: Justin Pachebat, IBERS, Aberystwyth University

Stream 5 - IBERS 0.33 (Monday), Physisc 0.11 (Tuesday & Wednesday)

Developing Drugs for Developing World Diseases: The Role of Patents
16:15 (45 mins)
Keynote Speaker: Katherine Ellis, Williams Powell

The challenges of commercialisation and industry adoption of novel parasite diagnostic tools
17:00 (30 mins)
Keynote Speaker: Greg Mirams, Techion Group Ltd

Commercialising Research a BioLine Perspective
17:30 (15 mins)
Mike Towey, Bioline

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Poster Session I & Drinks, Location: Students' Union
17:45 (90 mins)

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Poster Session I & Drinks, Location: Students' Union
17:45 (90 mins)

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British Ecology Society
BES SIG social :At the Royal Pier, Marine Terrace, Aberystwyth SY23 2AZ http://www.royalpier.co.uk

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Science Café. Parasites: The Good, the Bad, and the Ugly with Professors Alex Loukas, Peter Preiser, Rachel Chalmers

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8:00

Young Parasitologists Party - Location: Constitution Hill

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