Abstract

Benzodiazepines are well known as a key scaffold in medicinal chemistry providing bioactive compounds for a variety of biological targets. Among their primary use as anxiolytics and sedatives, the 1,4-benzodiazepine derivatives and their metabolites play a role as antitumor, antiviral and antimalarial agents. Recent studies revealed the influence of the benzodiazepine derivatives on the microtubule assembly or stability with subsequent mitotic failure. These microtubule-targeting effects were evaluated in novel benzodiazepine derivatives. The antiproliferative activities of novel derivatives were tested against a panel of 10 cancer cell lines and 2 non-cancer cell lines. The compounds with IC50