Wednesday, 30 November 2022 to Thursday, 1 December 2022

Thermal Shift Assays: Shifting from Manual to Automated Screening


M Collier1; K Hansel1; D Plant1; N Sims2; H Rowlands1; A Lanne1; A Broz3; E Ramsey3; H Plant1
1 Discovery Sciences, AstraZeneca, Alderley Park, UK;  2 HighRes BioSolutions, European Office, UK;  3 CBRE, Alderley Park, UK, UK


The Global High Throughput Screening Centre at AstraZeneca requires versatile automation to adapt to the many different assay formats carried out. We achieve this using modular systems based on HighRes BioSolution’s task-based CoLAB Flex carts e.g. dispense carts and reader carts. Individual Flex carts are controlled using A-cell robots, they are unshielded and can be run independently. Alternatively, 2 Flex carts can be docked together to form a semi-automated Cart2Cart system and up to 5 Flex carts can be docked around a central Kuka robot on a CoLAB Microstar. The AZ Automation Team has been working to automate two thermal shift assays; Differential scanning fluorimetry (DSF) and cellular thermal shift assay (CETSA)

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