Drug Discovery 2022: driving the next life science revolution

Genetic basis of phage-host interaction: Towards effective phage therapy of non-typhoidal Salmonella


M Mohammed1
1 University of Westminster, UK


Non-typhoidal Salmonella (NTS) have adapted to cause invasive illness in humans. Bacteria have developed MDR against current antibiotics. Bacteriophage therapy is the hope for bacterial treatment however one of the key limitations is
the limited host range of many phages and the ease of development of
bacterial resistance to phages. A solution is to develop one or a
cocktail of engineered phage that overcome these limitations. 

In this study, we used Anderson phage typing scheme as a valuable model system for study
of phage-host interaction to characterize all bacterial antiviral systems including CRISPRs, superinfection exclusion and
restriction-modification (R-M) systems) as well as phage evasion strategies
(including anti-CRISPRs). 

Understanding the dynmaics of bacteria-phage interaction would provide insights into phage biology and help in developing phage therapy against antibiotic resistant bacterial infections.

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