Tuesday, 9 November 2021 to Wednesday, 10 November 2021

Case studies in cellular nuisance compounds

Tue9  Nov11:50am(30 mins)
Where:
Helix Room
Session:
Speaker:
Dr Jayme Dahlin

Abstract

Nuisance compounds are a significant burden in chemical probe and drug discovery. These bad-acting compounds can interfere with the assay technology and/or produce genuine but undesirable bioactivity. While significant progress has been made to understand and mitigate the effects of nuisance compounds in cell-free systems, there are still many barriers to adequately address nuisance compounds in more complex cell-based assays. This presentation will describe several examples of nuisance compounds encountered in complex biological assays such as Cell Painting and live-cell imaging. Current efforts to address cellular nuisance compounds will be presented.
To view the video assoicated with this lecture click here
Youtube

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ELRIG

The European Laboratory Research & Innovation Group Our Vision : To provide outstanding, leading edge knowledge to the life sciences community on an open access basis