Drug Discovery 2022: driving the next life science revolution

Screening multiple PPI targets in parallel: accelerating portfolio-level decisions


G Mahe1P Kelly2; P Winship2; J Spencer2; J van Offenbeek1; K Nash2; M Vlaming1
1 Charles River Laboratories, NL, Netherlands;  2 Charles River Laboratories, UK, UK


HTS projects for multiple targets were developed in collaboration with our client and performed in parallel in a cross-site collaboration. Up to 370,000 compounds from a variety of chemical libraries were screened in a 1536-well plate format using TRFRET technology. During screening, plate effects were observed and investigated, the cause was attributed to shipment of assay ready plates on dry-ice.

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