Developing assay development tools to make screening less PAINS-full

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Abstract

Triaging the output from a screening campaign can be a long and difficult process. Experienced drug hunters often share tales of healthy hit lists slowly (or not so slowly) evaporating upon progressing through a cascade of orthogonal and de-selection assays. Worse still, tales of compounds producing consistent activity throughout the screening process which, following significant investment of resources, turn out to be exhibiting some difficult to diagnose assay or target interference behaviour. To try and minimise these issues BioAscent has created a library of compounds with known mechanisms of assay/target interference activity and a set of common salts and synthesis contaminants that we use during assay development to interrogate the sensitivity of assays to problem compounds. This talk will detail the changing use of this set and how it has impacted upon how we run projects.

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