Patient-derived cell models as a clinically-relevant drug discovery strategy

Time: To be announced
Where:
To be announced
 Gareth  Griffiths

Abstract

Cell lines often poorly represent the tumour of origin and are a major hurdle in establishing therapeutic targets and in understanding mechanisms that contribute to disease progression. To address this, research into growing cells from patient biopsies, sometimes called patient “avatars”, has progressed. Typically, these avatars are mice transplanted with the patient tumour tissue. These patient-derived xenografts (PDXs) are now firmly established as a model for testing drugs. They continue to face a number of drawbacks however. They can be difficult to establish, and the “take” rate can be between 0–51% depending on tumour type. Establishing models is also expensive and takes months. At Imagen we are creating models in vitro directly from the patient’s tumour and these represent a valid alternative to the PDX route. Patient-derived cell (PDC) models better represent original tumour characteristics than cell lines, and are quicker, less complex than PDX in-vivo models. Our data on multiple tumour types supports these models as powerful tools for drug discovery. Each of our models is phenotypically tested against 60 different therapies, is exome sequenced and has full RNAseq data generated. This allows specific cohorts of models to be chosen based upon particular biomarkers or, by being tumour agnostic, we can potentially discover new biomarkers using an AI approach.
To view the video assoicated with this lecture click here
Youtube

Hosted By

ELRIG

The European Laboratory Research & Innovation Group Our Vision : To provide outstanding, leading edge knowledge to the life sciences community on an open access basis
Web Site Find us on Facebook Follow us on Twitter

Get the App

Get this event information on your mobile by
going to the appstore or google play and search for 'elrig'
Login
Eventflo Home
copyright ELRIG, eventflo.co.uk, Labhoo Ltd 2003-2022