Fragment library screening by Grating Coupling Interferometry (GCI) and benefits over Surface Plasmon Resonance (SPR)

Poster
9

Fragment library screening by Grating Coupling Interferometry (GCI) and benefits over Surface Plasmon Resonance (SPR)

Authors

J Wolf2T Alleyne-Weir1; A O'Keeffe1; T Askwith1
1 Domainex Ltd, UK;  2 Doaminex Ltd, UK

Abstract

Domainex has
expanded its biophysics platform to incorporate the new Creoptix WAVE Delta system that uses Grating
Coupled Interferometry (GCI). GCI is analogous to Surface Plasmon Resonance
(SPR) systems where the target protein is immobilised on to specialised sensor
chips, however, the laser light travels over the entire length of the chip
rather than a single point and the novel fluidics enables measurements of very fast
off-rates
up to 10 s-1. This increases the sensitivity
as more binding events contribute to the overall signal, which is ideal to
identify weakly bound fragment hits. The newly launched waveRAPID technology
increases system throughput and compound handling time allowing full kinetic
characterisation with unattended loading capability for up to 400
compounds in 24 hours.


 



The poster will detail examples of fragment library
screening successes. 

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