Elucidation and characterisation of high throughput degrader screening outputs

Poster
8

Elucidation and characterisation of high throughput degrader screening outputs

Authors

L Bell1; G Davies1; G Holdgate1; J Kastl1; M Packer1
1 Hit Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK

Abstract

Targeted protein degradation is
an important function of the cellular machinery that is gaining momentum as an
exploitable strategy for drug discovery. Molecules that are able to induce
proximity between intractable therapeutic targets and the proteasomal
degradation machinery are slowly changing the druggable target landscape. Having
the ability to detect and understand the mechanism of action of hit molecules
identified from a direct screen for degraders is becoming increasingly
attractive. We have established a post-HTS cascade of experiments including
cell-based assays as well as orthogonal triage steps to provide annotation on
the selectivity and mechanism of action for primary screening hits against a
high value oncology target. We will describe our current position on the analysis
of these novel outputs and highlight challenges encountered.

Hosted By

ELRIG

The European Laboratory Research & Innovation Group Our Vision : To provide outstanding, leading edge knowledge to the life sciences community on an open access basis
Web Site Find us on Facebook Follow us on Twitter

Get the App

Get this event information on your mobile by
going to the appstore or google play and search for 'elrig'
Login
Eventflo Home
copyright ELRIG, eventflo.co.uk, Labhoo Ltd 2003-2022