MOLECULAR INTERACTION ANALYSIS BY GRATING-COUPLED INTERFEROMETRY (GCI)

Poster
2

MOLECULAR INTERACTION ANALYSIS BY GRATING-COUPLED INTERFEROMETRY (GCI)

Authors

E FitzGerald1; M Walton1
1 Creoptix AG, Switzerland

Abstract

GCI is a surface-based, label-free biosensing technique. When
target molecules (e.g. proteins) are attached to the sensor
surface, binding of analytes leads to an increase in mass and
hence to a change in the refractive index within the evanescent
field near the surface. In GCI, refractive index changes on a
sensor surface are measured as time-dependent phase-shift
signals. The long light-to-sample interaction length of the
waveguide provides intrinsically high signal-to-noise levels for
improved sensitivity. With high sensitivity, the ability to resolve
extremely rapid dissociating kinetics and innate compatibility
with high molecular weight ratios, the Creoptix® WAVEsystem’s
GCI technology improves fragment-based screening and
kinetic analysis of small molecules to accelerate drug
development. Paired with no-clog WAVEchips®, a wide range of
molecules can be immobilized using various chemistries

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