mRNA Lightning platform for the discovery of selective small molecule mRNA regulatory drugs

Tue19  Oct12:00pm(30 mins)
Where:
Hall 1B
Speaker:
Dr Iris Alroy

Abstract

Anima Biotech is advancing mRNA Lightning, a novel platform for the discovery of selective mRNA small molecules. Anima’s differentiated approach combines high-scale, automated, phenotypic cell-based screens with deep learning image analysis algorithms developed for mRNA regulation. Anima’s pipeline projects will be presented, demonstrating how mRNA-regulation target space is amenable to selective modulation by small molecules. The mRNA regulation target space includes proteins involved in RNA processing post-transcription and ends in mRNA translation by ribosomes. Anima’s mRNA translation modulators are not targeting the ribosomes or directly bind to mRNA but rather target a novel target space, proteins involved in the regulation of mRNA translation. By targeting these newly discovered cellular mechanisms that regulate mRNA biology, Anima discovered highly selective drugs against a broad range of challenging and seemingly undruggable targets. The small molecules have been shown to be tissue and/or disease specific, as they are targeting proteins that have specific biological roles in coordinating and regulating the translation of individual mRNAs and pathways.
To view the video assoicated with this lecture click here
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